Comparison of multiple dose GnRH antagonist and minidose long agonist protocols in poor responders undergoing in vitro fertilization: a randomized controlled trial

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dc.contributor.authorTazegül, Aybike
dc.contributor.authorGörkemli, Hüseyin
dc.contributor.authorÖzdemir, Suna
dc.contributor.authorAktan, Tahsin Murad
dc.date.accessioned2020-03-26T17:26:32Z
dc.date.available2020-03-26T17:26:32Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective To investigate the efficacy of gonadotropin releasing hormone antagonist (GnRH) in poor responders undergoing in vitro fertilization. Study design Ninety-six patients with poor ovarian response in previous treatment cycles were prospectively randomized into two groups. Forty-four patients were stimulated with GnRH antagonist multidose protocol and 45 patients received a standard long agonist protocol. Ovarian response was evaluated by transvaginal ultrasound and hormonal parameters. Cycle characteristics and treatment outcomes were statistically compared between groups. Results There was significantly reduced duration of stimulation and consumption of gonadotrophins in the antagonist group when compared to the agonist group. The estradiol concentrations on the day of human chorionic gonadotropin (hCG) injection, the number of oocytes retrieved, and the number of embryos transferred were similar for both groups. In the antagonist group, eight (18.1%) ongoing pregnancies were achieved and in the agonist group, ten (22.2%) clinical pregnancies were achieved but the difference was not statistically significant. Conclusions The present study was not powered to detect clinically relevant differences between two protocols in outcomes such as pregnancy rate, with confidence.en_US
dc.identifier.doi10.1007/s00404-008-0620-9en_US
dc.identifier.endpage472en_US
dc.identifier.issn0932-0067en_US
dc.identifier.issn1432-0711en_US
dc.identifier.issue5en_US
dc.identifier.pmid18335226en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage467en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00404-008-0620-9
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22270
dc.identifier.volume278en_US
dc.identifier.wosWOS:000259040400012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofARCHIVES OF GYNECOLOGY AND OBSTETRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGnRH antagonisten_US
dc.subjectGnRH long agonisten_US
dc.subjectin vitro fertilizationen_US
dc.subjectpoor responderen_US
dc.titleComparison of multiple dose GnRH antagonist and minidose long agonist protocols in poor responders undergoing in vitro fertilization: a randomized controlled trialen_US
dc.typeArticleen_US

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