Encapsulated boron as an osteoinductive agent for bone scaffolds
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER GMBH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to develop boron (B)-releasing polymeric scaffold to promote regeneration of bone tissue. Boric acid-doped chitosan nanoparticles with a diameter of approx. 175 nm were produced by tripolyphosphate (TPP)-initiated ionic gelation process. The nanoparticles strongly attached via electrostatic interactions into chitosan scaffolds produced by freeze-drying with approx. 100 pm pore diameter. According to the ICP-OES results, following first 5 h initial burst release, fast release of B from scaffolds was observed for 24 h incubation period in conditioned medium. Then, slow release of B was performed over 120 h. The results of the cell culture studies proved that the encapsulated boron within the scaffolds can be used as an osteoinductive agent by showing its positive effects on the proliferation and differentiation of MC3T3-E1 preosteoblastic cells. (C) 2015 Elsevier GmbH. All rights reserved.
Açıklama
Anahtar Kelimeler
Boron, Bone tissue engineering, Scaffold, Nanoparticle, Chitosan
Kaynak
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
31