Comparison of Open and Retroperitonoscopic Donor Nephrectomy in Terms of Lipid and Protein Peroxidation Responses

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dc.contributor.authorDinckan, A.
dc.contributor.authorDinc, B.
dc.contributor.authorTurkyilmaz, S.
dc.contributor.authorTekin, A.
dc.contributor.authorKocak, H.
dc.contributor.authorAkbas, H.
dc.contributor.authorMesci, A.
dc.date.accessioned2020-03-26T18:41:20Z
dc.date.available2020-03-26T18:41:20Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground. This study was designed to compare donors who underwent open (ODN) versus retroperitonoscopic nephrectomy (RDN) in terms of intra-operative oxidative stress and recipients graft function in the early postoperative period. Methods. Among 40 patients who underwent donor nephrectomy, 23 were operated via an open method and 17 via retroperitonoscopic method. To analyze oxidative stress, we measured plasma levels of malondialdehyde (MDA), protein carbonyl, and protein sulfhydryl moieties in donor venous blood before induction of anesthesia and postoperatively at 0, 6, and 24 hours. The influence of oxidative stress on graft function was evaluated by means of the postoperative 5th day recipient creatinine and estimated glomerular filtration rate (eGFR) Modification of Diet in Renal Disease Formula (MDRD) to evaluate delayed graft function (DGF) status. Results. ODN patients showed significantly higher 24-hour mean levels of MDA, (6,139 +/- 1,854 vs 4,813 +/- 1,771 nmol/L; P =.01), protein carbonyl (366 +/- 64 vs 311 +/- 62 innol/L; P =.01) and protein sulfhydryl (468 +/- 110 vs 386 +/- 75 umol/L; P =.01) moieties compared with those RDN patients. However, ODN and RDN recipients were similar in terms of 5th day mean creatinine and eGFR (1.1 +/- 0.3 vs 1.4 +/- 0.8 mg/dL and 69.15 +/- 12.24 vs 56.31 +/- 25.2, respectively) and DGF status (4.4% [1/23] vs 5.9% [1/17], respectively). Conclusions. Although ODN donors were more prone to intra-operative oxidative stress than RDN donors, based on significantly higher levels of oxidative stress markers, this difference seems to not significantly influence recipients early graft function.en_US
dc.identifier.doi10.1016/j.transproceed.2013.06.018en_US
dc.identifier.endpage3219en_US
dc.identifier.issn0041-1345en_US
dc.identifier.issn1873-2623en_US
dc.identifier.issue9en_US
dc.identifier.pmid24182787en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3214en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.transproceed.2013.06.018
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29317
dc.identifier.volume45en_US
dc.identifier.wosWOS:000326709400013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofTRANSPLANTATION PROCEEDINGSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleComparison of Open and Retroperitonoscopic Donor Nephrectomy in Terms of Lipid and Protein Peroxidation Responsesen_US
dc.typeArticleen_US

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