Calixarene Nanofiber Design for Human Colon Cancer 3D-Cell Culture
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
IEEE
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A growing body of evidence has suggested that 3D cell culture systems, in contrast to the 2D systems, represent more accurately the actual microenvironment where cells reside in tissues. Therefore, researchers have concentrated on developing realistic and sophisticated in-vitro 3D cell culture models that actually resemble the complex environment of native tissues. Calixarenes, similar to a ring basket, represent a third generation of supramolecular hosts could be promising candidates in this regard. Due to having a cyclic structure and large surface area, calixarenes, can be functionalized easily with polar and apolar groups, be a good carrier for cations, anions and neutral molecules. Electrospinning of p-tert-butylcalix[4] arene nanofibers with different functional groups were performed and their endothelial (Caco-2) and fibroblastic (L-929) cytocompatibility behaviour on cell adhesion function were examined. Cell attachment kinetics revealed that the (Caco-2) and L-929 attached to the nanofibers functionalized with pyridinumat position 3 at the same rate as to tissue culture plates. In this report, for the first time in literature, it was shown that 3D cultured systems designed with calixarene nanofibers provide excellent in vitro models, allowing the study of cellular responses in a setting that resembles in vivo environments.
Açıklama
7th IEEE International Conference Nanomaterials - Application and Properties (NAP) -- SEP 10-15, 2017 -- Odessa, UKRAINE
Anahtar Kelimeler
Calixarene, Electrospinning, Nanofiber, 3D-Cell Culture, Surface Funtionalization
Kaynak
PROCEEDINGS OF THE 2017 IEEE 7TH INTERNATIONAL CONFERENCE NANOMATERIALS: APPLICATION & PROPERTIES (NAP)
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
