Calixarene Nanofiber Design for Human Colon Cancer 3D-Cell Culture

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dc.contributor.authorArpacı, P. Uyar
dc.contributor.authorÖzcan, Fatih
dc.contributor.authorAğaç, Müslüm
dc.contributor.authorErtul, Şeref
dc.date.accessioned2020-03-26T19:34:10Z
dc.date.available2020-03-26T19:34:10Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description7th IEEE International Conference Nanomaterials - Application and Properties (NAP) -- SEP 10-15, 2017 -- Odessa, UKRAINEen_US
dc.description.abstractA growing body of evidence has suggested that 3D cell culture systems, in contrast to the 2D systems, represent more accurately the actual microenvironment where cells reside in tissues. Therefore, researchers have concentrated on developing realistic and sophisticated in-vitro 3D cell culture models that actually resemble the complex environment of native tissues. Calixarenes, similar to a ring basket, represent a third generation of supramolecular hosts could be promising candidates in this regard. Due to having a cyclic structure and large surface area, calixarenes, can be functionalized easily with polar and apolar groups, be a good carrier for cations, anions and neutral molecules. Electrospinning of p-tert-butylcalix[4] arene nanofibers with different functional groups were performed and their endothelial (Caco-2) and fibroblastic (L-929) cytocompatibility behaviour on cell adhesion function were examined. Cell attachment kinetics revealed that the (Caco-2) and L-929 attached to the nanofibers functionalized with pyridinumat position 3 at the same rate as to tissue culture plates. In this report, for the first time in literature, it was shown that 3D cultured systems designed with calixarene nanofibers provide excellent in vitro models, allowing the study of cellular responses in a setting that resembles in vivo environments.en_US
dc.description.sponsorshipIEEE, Minist Educ Sci Ukraineen_US
dc.identifier.isbn978-1-5386-2810-2
dc.identifier.issn2306-580Xen_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34853
dc.identifier.wosWOS:000426973100161en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIEEEen_US
dc.relation.ispartofPROCEEDINGS OF THE 2017 IEEE 7TH INTERNATIONAL CONFERENCE NANOMATERIALS: APPLICATION & PROPERTIES (NAP)en_US
dc.relation.ispartofseriesProceedings of the international conference Nanomaterials-Applications and properties
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCalixareneen_US
dc.subjectElectrospinningen_US
dc.subjectNanofiberen_US
dc.subject3D-Cell Cultureen_US
dc.subjectSurface Funtionalizationen_US
dc.titleCalixarene Nanofiber Design for Human Colon Cancer 3D-Cell Cultureen_US
dc.typeConference Objecten_US

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