Assessment of ischaemia-modified albumin level in patients with psoriasis

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dc.contributor.authorOzdemir, M.
dc.contributor.authorKiyici, A.
dc.contributor.authorBalevi, A.
dc.contributor.authorMevlitoglu, I.
dc.contributor.authorPeru, C.
dc.date.accessioned2020-03-26T18:23:59Z
dc.date.available2020-03-26T18:23:59Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground. Ischaemia-modified albumin (IMA) is increased in diseases associated with oxidative stress, as detected using the albumin cobalt-binding test. Oxidative stress plays an important role in the development of psoriasis. Aim. To investigate circulating IMA levels in patients with psoriasis and its association with the disease characteristics. Methods. Serum IMA and albumin concentrations were evaluated in 26 patients with psoriasis and 26 healthy controls matched for age, gender and body mass index. Levels of albumin, IMA and adjusted IMA were compared between the groups. Results. IMA and adjusted IMA were significantly higher in patients with psoriasis [0.55 +/- 0.04 and 0.54 +/- 0.05 absorbance units (ABSU), respectively] than in healthy controls (0.38 +/- 0.04 and 0.38 +/- 0.05 ABSU, respectively). The two groups had similar albumin levels, but there was a negative correlation between IMA and albumin levels in patients with psoriasis. IMA did not correlate with any disease characteristics. Conclusions. IMA levels are higher in patients with psoriasis than in healthy controls. IMA might be produced through an adaptive response to chronic hypoxia and oxidative stress, which might play a role in the systemic inflammation seen in psoriasis.en_US
dc.identifier.doi10.1111/j.1365-2230.2012.04384.xen_US
dc.identifier.endpage614en_US
dc.identifier.issn0307-6938en_US
dc.identifier.issue6en_US
dc.identifier.pmid22607558en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage610en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1365-2230.2012.04384.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27765
dc.identifier.volume37en_US
dc.identifier.wosWOS:000306665000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofCLINICAL AND EXPERIMENTAL DERMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleAssessment of ischaemia-modified albumin level in patients with psoriasisen_US
dc.typeArticleen_US

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