Comparative Pharmacokinetics and Metabolisms of Caffeine in Sheep Breeds

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dc.contributor.authorUney, Kamil
dc.contributor.authorTras, Bunyamin
dc.date.accessioned2020-03-26T18:13:58Z
dc.date.available2020-03-26T18:13:58Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe purpose of this study was to investigate the effect of breed on the pharmacokinetics and metabolism of caffeine (CF) and the hepatic metabolic capacity in sheep. CF was administered as a single intravenous dose of 5 mg/kg b.w. in Morkaraman (MK), Akkaraman (AK) and Anatolia Merino (AM) sheep breeds. The plasma levels of CF and its primary metabolites, theobromine (TB), paraxanthine (PX) and theophylline (TP), were measured using high-performance liquid chromatography. Pharmacokinetic parameters of CF and its metabolites were calculated. Plasma TB+PX+TP/CF metabolic ratio was determined as an alternative to CF clearance for the determination of hepatic metabolic capacity. In the three breeds, all kinetic parameters of CF differed significantly (P<0.05) except for volume of distribution. Elimination of CF was slow in the MK (Cl(T); 0.03 +/- 0.01 l hr/kg, t(1/2 lambda z); 15.74 +/- 7.35 hr) and AM (Cl(T); 0.05 +/- 0.02 / hr/kg, t(1/2 lambda z); 9.68 +/- 5.21 hr) breeds when compared with the AK breed (Cl(T); 0.08 +/- 0.01 l hr/kg, t(1/2 lambda z), 6.84 +/- 0.79 hr). There was significant correlation (r(2)=0.904, P<0.01) between CF clearance and the plasma TB+PX+TP/CF ratio calculated at 7 hr after CF administration. The plasma TB+PX+TP/CF ratios were statistically different (P<0.05) among the breeds (MK, 0.155 +/- 0.062; AK, 0.468 +/- 0.107; AM, 0.254 +/- 0.099). These results suggest that the pattern of drug biotransformation should be consistently tested for all breeds within species. Further studies are needed to determine the biochemical and molecular events underlying such an effect.en_US
dc.description.sponsorshipSUBAPK (University of Selcuk)Selcuk University [06102001]en_US
dc.description.sponsorshipThis study was summarized from a PhD thesis and supported by SUBAPK (The Coordination of Scientific Research Projects, University of Selcuk, Project No: 06102001).en_US
dc.identifier.doi10.1292/jvms.09-0580en_US
dc.identifier.endpage31en_US
dc.identifier.issn0916-7250en_US
dc.identifier.issue1en_US
dc.identifier.pmid20736520en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://dx.doi.org/10.1292/jvms.09-0580
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26246
dc.identifier.volume73en_US
dc.identifier.wosWOS:000287680800005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJAPAN SOC VET SCIen_US
dc.relation.ispartofJOURNAL OF VETERINARY MEDICAL SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbreeden_US
dc.subjectcaffeineen_US
dc.subjecthepatic metabolic capacityen_US
dc.subjectpharmacokineticsen_US
dc.subjectsheepen_US
dc.titleComparative Pharmacokinetics and Metabolisms of Caffeine in Sheep Breedsen_US
dc.typeArticleen_US

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