Prognostic value of preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, and multiphasic renal tomography findings in histological subtypes of renal cell carcinoma

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dc.contributor.authorKeskin, Suat
dc.contributor.authorKeskin, Zeynep
dc.contributor.authorTaskapu, Hakan Hakki
dc.contributor.authorKalkan, Havva
dc.contributor.authorKaynar, Mehmet
dc.contributor.authorPoyraz, Necdet
dc.contributor.authorToy, Hatice
dc.date.accessioned2020-03-26T18:58:26Z
dc.date.available2020-03-26T18:58:26Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: To determine the relationship between renal cell carcinoma subtypes and the associated mortality and biochemical parameters. An additional aim was to analyze multiphasic multidetector computed tomography findings. Methods: This study is a hospital-based retrospective investigation, using 211 patients with a diagnosis of renal cell carcinoma upon computed tomography examination. The histological subtypes included clear cell in 119 patients, chromophobe cell in 30 patients, papillary cell in 25 patients, mixed cell in 32 patients, and sarcomatoid cell in 4 patients. Results: The mean age of the patients participating in this study was 61.18 +/- 11.81 years, and the mortality rate was 10.4% (n = 22) through the 2-year follow-up. The ratios of both the neutrophil-to-lymphocyte upon admission to the hospital and platelet-to-lymphocyte of the non-surviving group were significantly higher than those of the surviving group (p < 0.05). When the analysis of the 2-year survival of the patients was examined according to the median platelet-to-lymphocyte ratio values, the Kaplan-Meier survival curves were significantly different between the surviving and non-surviving groups (p = 0.01). In two-way analysis of variance test, statistically significant results which were influenced by mortality (p = 0.028) and were found between renal cell carcinoma subtypes in the computed tomography density of corticomedullary phase (p = 0.001). Conclusions: The neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio may represent widely available biomarkers in renal cell carcinoma, and the logistic regression model indicated that neutrophil-to-lymphocyte ratio was a significant predictor for mortality. According to the median platelet-to-lymphocyte ratio values, the Kaplan-Meier survival curves were significantly different between the surviving and non-surviving groups.en_US
dc.description.sponsorshipDepartment of Urology in Necmettin Erbakan University Meram School of MedicineNecmettin Erbakan Universityen_US
dc.description.sponsorshipThis work was supported by Department of Urology in Necmettin Erbakan University Meram School of Medicine.en_US
dc.identifier.doi10.1186/1471-2490-14-95en_US
dc.identifier.issn1471-2490en_US
dc.identifier.pmid25427576en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1186/1471-2490-14-95
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31090
dc.identifier.volume14en_US
dc.identifier.wosWOS:000348386000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.relation.ispartofBMC UROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRenal cell carcinomaen_US
dc.subjectNeutrophil-to-lymphocyte ratioen_US
dc.subjectPlatelet-to-lymphocyte ratioen_US
dc.subjectMultiphasic multidetector tomographyen_US
dc.subjectMortalityen_US
dc.titlePrognostic value of preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, and multiphasic renal tomography findings in histological subtypes of renal cell carcinomaen_US
dc.typeArticleen_US

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