Effects of bcrp and p-gp modulators on the penetration of aflatoxin b1 into the mouse brain

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dc.contributor.authorTras, Bunyamin
dc.contributor.authorCetin, Gul
dc.contributor.authorUney, Kamil
dc.contributor.authorDik, Burak
dc.contributor.authorCorum, Orhan
dc.contributor.authorAtalay, Sema
dc.date.accessioned2020-03-26T19:35:18Z
dc.date.available2020-03-26T19:35:18Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractThis study was conducted to determine whether the plasma and brain concentrations of AFB(1) are affected by the modulation of P-gp and BCRP using zosuquidar (ZQR) and prazosin (PRZ), respectively. In this study, a total of 40 healthy adult male BALB/c mice (32 +/- 3.7 g) were used. The animals were randomly divided into 5 groups, with 8 animals per group. Group 1 was used for method validation. Group 2 (AF) received intraperitoneal AFB1 at a dose of 20 mg/kg of body weight. Groups 3 (AF+PRZ), 4 (AF+ZQR), and 5 (AF+PRZ+ZQR) received 20 mg/kg of AFB(1) intraperitoneally 30 min after the intraperitoneal administration of prazosin (0.3 mg/kg), zosuquidar (25 mg/kg), and prazosin+zosuquidar (0.3 mg/kg prazosin + 25 mg/kg zosuquidar), respectively. Six hours after the administration of AFB(1), blood and brain samples were collected from the animals in Groups 2 to 5. AFB(1) concentrations were determined using an HPLC system with fluorescence detection. Individual and simultaneous administration of prazosin and zosuquidar significantly reduced the brain concentrations of AFB(1) in comparison to a single administration of AFB(1) (P<0.05). The brain/plasma ratio of the AF group was higher than that of the other groups (AF+PRZ, AF+ZQR, and AF+PRZ+ZQR) (P<0.05). Inducers of transmembrane proteins, especially BCRP, can be life saving during acute AFB(1) poisoning.en_US
dc.identifier.citationTras, B., Cetin, G., Uney, K., Dik, B., Corum, O., Atalay, S. (2017). Effects of BCRP and P-gp Modulators on the Penetration of Aflatoxin B1 into the Mouse Brain. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 23(1), 95-100.
dc.identifier.doi10.9775/kvfd.2016.15904en_US
dc.identifier.endpage100en_US
dc.identifier.issn1300-6045en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://dx.doi.org/10.9775/kvfd.2016.15904
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35031
dc.identifier.volume23en_US
dc.identifier.wosWOS:000388115200013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTras, Bunyamin
dc.institutionauthorUney, Kamil
dc.institutionauthorDik, Burak
dc.language.isoenen_US
dc.publisherKAFKAS UNIV, VETERINER FAKULTESI DERGISIen_US
dc.relation.ispartofKAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAflatoxin B-1en_US
dc.subjectBrainen_US
dc.subjectDrug transporter proteinsen_US
dc.subjectModulationen_US
dc.subjectMiceen_US
dc.titleEffects of bcrp and p-gp modulators on the penetration of aflatoxin b1 into the mouse brainen_US
dc.typeArticleen_US

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