Repeated in vitro Fertilization Failure and Its Relation with Thrombophilia

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dc.contributor.authorSimur, Aynur
dc.contributor.authorOezdemir, Suna
dc.contributor.authorAcar, Hasan
dc.contributor.authorColakoglu, M. Cengiz
dc.contributor.authorGoerkemli, Hueyin
dc.contributor.authorBalci, Osman
dc.contributor.authorNergis, Sueleyman
dc.date.accessioned2020-03-26T17:40:00Z
dc.date.available2020-03-26T17:40:00Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The objective of this study was to determine the prevalence of some thrombophilic factors and its relation to in vitro fertilization (IVF)-embryo transfer failure in women who had had three or more previously failed IVF-embryo transfer cycles. Methods: The study group included 51 consecutive women with three or more previously failed IVF-embryo transfer cycles (group 1). The control group included 50 women who conceived spontaneously with at least one uneventful pregnancy and no previous history of miscarriage. All women were tested for the presence of factor V Leiden, prothrombin (G20210A), and methylenetetrahydrofolate reductase (C677T) mutations. Results: A similar prevalence of factor V Leiden, prothrombin, and methylenetetrahydrofolate reductase mutations was found in both groups. At least one inherited thrombophilic factor was detected in 62.7% of women with repeated IVF failure and in 53.9% of women in group 2. No association between repeated IVF failure and these thrombophilic factors was found statistically. Conclusion: These data suggest that factor V Leiden, methylenetetrahydrofolate reductase and prothrombin gene mutation do not have a significant role in IVF-embryo transfer implantation failure. Copyright (C) 2008 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000165776en_US
dc.identifier.endpage112en_US
dc.identifier.issn0378-7346en_US
dc.identifier.issn1423-002Xen_US
dc.identifier.issue2en_US
dc.identifier.pmid18957855en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000165776
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23827
dc.identifier.volume67en_US
dc.identifier.wosWOS:000263131700006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofGYNECOLOGIC AND OBSTETRIC INVESTIGATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectImplantation failureen_US
dc.subjectIn vitro fertilization-embryo transferen_US
dc.subjectThrombophiliaen_US
dc.titleRepeated in vitro Fertilization Failure and Its Relation with Thrombophiliaen_US
dc.typeArticleen_US

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