Clinical and biochemical effects of diode laser as an adjunct to nonsurgical treatment of chronic periodontitis: a randomized, controlled clinical trial

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dc.contributor.authorSaglam, Mehmet
dc.contributor.authorKantarci, Alpdogan
dc.contributor.authorDundar, Niyazi
dc.contributor.authorHakki, Sema S.
dc.date.accessioned2020-03-26T18:49:43Z
dc.date.available2020-03-26T18:49:43Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this randomized, parallel, controlled clinical trial was to examine the clinical and biochemical efficacy of diode laser as an adjunct to scaling and root planing (SRP). Thirty chronic periodontitis patients were randomly assigned into two groups to receive SRP alone (control) or SRP followed by diode laser (test). Plaque index, gingival index, bleeding on probing, probing depth, and clinical attachment level were measured at baseline and at 1, 3, and 6 months after treatment. The gingival crevicular fluid levels of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-8 (MMP-8) and tissue inhibitor matrix metalloproteinase-1 (TIMP-1) were analyzed by enzyme-linked immunosorbent assay. Test group showed significantly a better outcome compared to the control group in full-mouth clinical parameters. MMP-1, MMP-8, and TIMP-1 showed significant differences between groups after treatment compared to baseline (p < 0.05). The total amount of IL-1 beta, IL-6, MMP-1, MMP-8, and TIMP-1 decreased (p < 0.05) and IL-8 increased after treatment in both test and control groups (p < 0.05). Diode laser provided significant improvements in clinical parameters and MMP-8 was significantly impacted by the adjunctive laser treatment at first month providing an insight to how lasers can enhance the outcomes of the nonsurgical periodontal therapy.en_US
dc.description.sponsorshipScientific Research Coordination Office of Selcuk University, Konya, TurkeySelcuk University; The Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK/SBAG-110S502]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Coordination Office of Selcuk University, Konya, Turkey and The Scientific and Technological Research Council of Turkey (TUBITAK/SBAG-110S502). The authors report no conflicts of interest related to this study.en_US
dc.identifier.doi10.1007/s10103-012-1230-0en_US
dc.identifier.endpage46en_US
dc.identifier.issn0268-8921en_US
dc.identifier.issn1435-604Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid23161345en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10103-012-1230-0
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30670
dc.identifier.volume29en_US
dc.identifier.wosWOS:000329834200005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER LONDON LTDen_US
dc.relation.ispartofLASERS IN MEDICAL SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiode lasersen_US
dc.subjectChronic periodontitisen_US
dc.subjectNonsurgical periodontal debridementen_US
dc.subjectCytokinesen_US
dc.subjectMatrix metalloproteinase 1en_US
dc.subjectMatrix metalloproteinase 8en_US
dc.titleClinical and biochemical effects of diode laser as an adjunct to nonsurgical treatment of chronic periodontitis: a randomized, controlled clinical trialen_US
dc.typeArticleen_US

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