Synthesis of benzimidazole Schiff base derivatives and cytotoxic effects on colon and cervix cancer cell lines
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
BIOINTERFACE RESEARCH APPLIED CHEMISTRY
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
During the last few years the potential of benzimidazole derivatives in agrochemical and medicinal properties have been subjected to investigation. benzimidazole derivatives have been received central attention due to their significant antimicrobial, antibacterial, antifungal, anti-HIV, anticancer, and a wide array of other biological activities. The formation of 2-aryl-substituted benzimidazoles, by the polyphosphoric acid-catalyzed condensation of a carboxylic acid, with an o-amino-arylamine is described. The condensations proceed in good yield to give products which, in certain instances, are not readily attainable by conventional condensation techniques. The study of Benzimidazole containing Schiff bases is also of interest as some of them have shown the ability to anticancer. The structures of the compounds were identified by FT-IR, H-1 NMR, C-13 NMR and elemental analysis. Cytotoxic effects of benzimidazole derivatives on human cervical and colon cancer cell lines HeLa and SW-620 was determined spectrophotometrically by using Alamar Blue. Benzimidazole derivatives selectively inhibited proliferation of cancerous cell lines. None of the benzimidazole Schiff base derivatives inhibits proliferation of SW-620 while 4-APbzlH, 4SAPbz1H and 3SAPbz1H dose dependently inhibit proliferation of HeLa cells with IC50 of 230 mu M, 110.6 mu M and 101.3 mu M, respectively.
Açıklama
Anahtar Kelimeler
Benzimidazole, Schiff base, cytotoxicity, anticancer, HeLa, SW-620
Kaynak
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
7
Sayı
4
