Synthesis of benzimidazole Schiff base derivatives and cytotoxic effects on colon and cervix cancer cell lines

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dc.contributor.authorArslaner, Cennet
dc.contributor.authorKarakurt, Serdar
dc.contributor.authorKoc, Ziya Erdem
dc.date.accessioned2020-03-26T19:42:44Z
dc.date.available2020-03-26T19:42:44Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractDuring the last few years the potential of benzimidazole derivatives in agrochemical and medicinal properties have been subjected to investigation. benzimidazole derivatives have been received central attention due to their significant antimicrobial, antibacterial, antifungal, anti-HIV, anticancer, and a wide array of other biological activities. The formation of 2-aryl-substituted benzimidazoles, by the polyphosphoric acid-catalyzed condensation of a carboxylic acid, with an o-amino-arylamine is described. The condensations proceed in good yield to give products which, in certain instances, are not readily attainable by conventional condensation techniques. The study of Benzimidazole containing Schiff bases is also of interest as some of them have shown the ability to anticancer. The structures of the compounds were identified by FT-IR, H-1 NMR, C-13 NMR and elemental analysis. Cytotoxic effects of benzimidazole derivatives on human cervical and colon cancer cell lines HeLa and SW-620 was determined spectrophotometrically by using Alamar Blue. Benzimidazole derivatives selectively inhibited proliferation of cancerous cell lines. None of the benzimidazole Schiff base derivatives inhibits proliferation of SW-620 while 4-APbzlH, 4SAPbz1H and 3SAPbz1H dose dependently inhibit proliferation of HeLa cells with IC50 of 230 mu M, 110.6 mu M and 101.3 mu M, respectively.en_US
dc.description.sponsorshipResearch Foundation of Selcuk UniversitySelcuk University [15201079]en_US
dc.description.sponsorshipThis work is supported by The Research Foundation of Selcuk University (project number: 15201079).en_US
dc.identifier.endpage2107en_US
dc.identifier.issn2069-5837en_US
dc.identifier.issue4en_US
dc.identifier.pmid#YOKen_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2103en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35509
dc.identifier.volume7en_US
dc.identifier.wosWOS:000416249200004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBIOINTERFACE RESEARCH APPLIED CHEMISTRYen_US
dc.relation.ispartofBIOINTERFACE RESEARCH IN APPLIED CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBenzimidazoleen_US
dc.subjectSchiff baseen_US
dc.subjectcytotoxicityen_US
dc.subjectanticanceren_US
dc.subjectHeLaen_US
dc.subjectSW-620en_US
dc.titleSynthesis of benzimidazole Schiff base derivatives and cytotoxic effects on colon and cervix cancer cell linesen_US
dc.typeArticleen_US

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