The Effects of Free Radicals on Antioxidant Defence Systems and Organism in Hemodialysis Patients

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dc.contributor.authorYontem, Mustafa
dc.contributor.authorBilge, Murat
dc.contributor.authorKaleli, Suleyman
dc.contributor.authorKurban, Sevil
dc.contributor.authorCelik, Gulperi
dc.date.accessioned2020-03-26T18:16:50Z
dc.date.available2020-03-26T18:16:50Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractChronic Renal Failure (CRF) is accompanied by a variety of complications which may develop due to an increase in oxidant stress and/or a decrease in antioxidant activities. Hemodialysis (HD) is still the most prevalent method used for the end stage renal failure throughout the world. In this study, it was aimed to research thoroughly whether an increase in lipid peroxidation occurs in hemodialysis patients with advanced CRF and to evaluate antioxidant enzyme activities. Plasma MDA which is the indicator of lipid peroxidation and plasma SOD, CAT, GSH-Px levels as well as total antioxidant status (TAS) values which are the indicators of antioxidant defense systems have been determined in CRF patients who have undergone hemodialysis treatment and in the control group. Compared to those found in the control group, MDA and SOD levels in CRF patient group have statistically increased (p<0,001), while GSH-Px and CAT values have been found to decrease (p<0,001). TAS values have been determined to increase in the control group before the hemodialysis and to decrease after the hemodialysis, which is statistically insignificant. With regard to the correlation calculation we've made, a statistically positive correlation have been found between urea and creatinine both pre- and after hemodialysis, while no statistically significance have been recorded among other parameters.en_US
dc.description.sponsorshipDumlupinar UniversityDumlupinar University [2008-10]en_US
dc.description.sponsorshipThis study was supported by the Dumlupinar University within research project no 2008-10.en_US
dc.identifier.endpage394en_US
dc.identifier.issn0253-5106en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage389en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26934
dc.identifier.volume33en_US
dc.identifier.wosWOS:000293956000016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCHEM SOC PAKISTANen_US
dc.relation.ispartofJOURNAL OF THE CHEMICAL SOCIETY OF PAKISTANen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe Effects of Free Radicals on Antioxidant Defence Systems and Organism in Hemodialysis Patientsen_US
dc.typeArticleen_US

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