The effect of vitamin D on MCF-7 breast cancer cell metabolism

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dc.contributor.authorSaraçlıgil, B.
dc.contributor.authorÖztürk, B.
dc.contributor.authorÜnlü, Ali
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorTekin, G.
dc.date.accessioned2020-03-26T19:42:55Z
dc.date.available2020-03-26T19:42:55Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe role of vitamin D in calcium absorption and bone health is known. The studies revealed that vitamin D modulates breast cancer cell growth and it is also associated with a reduced breast cancer risk. The primary objective of this study was to highlight the metabolic effect of Vitamin D on MCF-7 breast cancer cell line. For that purpose, we checked the apoptosis, energy, amino-acid and acylcarnitine levels in cancer cells, that the study propose, that la, 25(OH)(2)D-3 could inhibit cell growth in a dose and time dependent manner. IC50 dose was calculated as 145 nM for vitamin D. We observed the apoptosis level in vitamin D groups, which were 18, 28 and 38.5 % at 24, 48 and 72 hours, respectively. During metabolic screening analysis, it was observed that glutamine, methionine and glutamic acid levels were treated more by Vitamin D groups in cell line and also, that acylcarnitine level was increased in 24 and 48 hour groups when compared to the control, but decreased in 72 hours. Further studies are needed to analyze the role of amino acids and acylcarnitines for early apoptosis and cancer metabolism (Tab. 2, Fig. 4, Ref. 24). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2017_021en_US
dc.identifier.endpage106en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue2en_US
dc.identifier.pmid28814091en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2017_021
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35557
dc.identifier.volume118en_US
dc.identifier.wosWOS:000395357800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectvitamin Den_US
dc.subjectapoptosisen_US
dc.subjectenergyen_US
dc.subjectamino-acid and acylcarnitine levelsen_US
dc.titleThe effect of vitamin D on MCF-7 breast cancer cell metabolismen_US
dc.typeArticleen_US

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