The effect of Halofuginone in the amelioration of radiation induced-lung fibrosis

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dc.contributor.authorYavas, Guler
dc.contributor.authorCalik, Mustafa
dc.contributor.authorCalik, Goknil
dc.contributor.authorYavas, Cagdas
dc.contributor.authorAta, Ozlem
dc.contributor.authorEsme, Hidir
dc.date.accessioned2020-03-26T18:43:53Z
dc.date.available2020-03-26T18:43:53Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe lung is one of the most sensitive organs to ionizing radiation, and damage to normal lung tissue remains a major dose limiting factor for patients receiving radiation to the thorax. Radiation induced lung injury (RILI) which is also named as "radiation pneumonpathy" is a continuous process and regarded as the result of an abnormal healing response. It has been shown that transforming growth factor beta-1 (TGF-beta 1) plays an integral role in the radiation induced lung fibrosis formation by promoting the chemoattraction of fibroblasts and their conversion to myofibroblasts. Halofuginone is a, low molecular weight plant derived alkaloid, isolated from the Dichroa febnfuga plant that exhibits antifibrotic activity and inhibition of type I collagen synthesis. Halofuginone has been shown to protect against radiation induced soft tissue fibrosis by virtue of inhibiting various members of TFG-beta signaling pathway. By the light of these findings, we hypothesize that Halofuginone may be able to ameliorate the radiation induced lung fibrosis. (C) 2013 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.mehy.2013.01.001en_US
dc.identifier.endpage359en_US
dc.identifier.issn0306-9877en_US
dc.identifier.issn1532-2777en_US
dc.identifier.issue4en_US
dc.identifier.pmid23352286en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage357en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.mehy.2013.01.001
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29907
dc.identifier.volume80en_US
dc.identifier.wosWOS:000317164500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCHURCHILL LIVINGSTONEen_US
dc.relation.ispartofMEDICAL HYPOTHESESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe effect of Halofuginone in the amelioration of radiation induced-lung fibrosisen_US
dc.typeArticleen_US

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