Effects of treatment with coenzyme Q(10) on exercised rat aorta

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dc.contributor.authorOkudan, Nilsel
dc.contributor.authorAtalık, Kısmet Esra Nurullahoğlu
dc.contributor.authorRevan, S.
dc.contributor.authorBelviranlı, Muaz
dc.contributor.authorBalcı, Şükrü Serdar
dc.contributor.authorGökbel, Hakkı
dc.contributor.authorPepe, H.
dc.date.accessioned2020-03-26T18:25:21Z
dc.date.available2020-03-26T18:25:21Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, the effect of long-term supplementation of coenzyme Q(10) (CoQ(10)) on the responses of swim-trained rat aorta was investigated. Twenty-four adult male Wistar rats were divided into four groups: untrained, trained, untrained+CoQ(10), and trained+CoQ(10) group. In the trained groups rats swam for 60 min/day, five days/week for six weeks. The CoQ(10) supplements were administered by intraperitoneal injection at a daily dose of 10 mg.kg(-1) of body weight five days/week for six weeks. Swimming of the rats was performed in a container containing tap water. Rats were sacrificed and thoracic aortas were removed for ex vivo analysis after the last swimming session. The aortas were cut into rings 2.5 mm in length. Concentration-response curves for phenylephrine (PHE, 10(-9)-3x10(-4) M) and potassium chloride (KCl, 5-100 mM) were isometrically recorded. The sensitivity and maximal responses to PHE and KCl of aortic rings obtained from trained rats were lower than those of untrained rats. CoQ(10) supplementation decreased the responses to both vasoconstrictors in untrained and especially in trained groups. Although neither CoQ(10) nor training did affect malondialdehyde (MDA) and protein carbonyl (PC) levels, creatine kinase (CK) activity decreased and superoxide dismutase (SOD) activity increased only with exercise training. Glutathione (GSH) levels increased in CoQ(10) supplemented-untrained rats. In conclusion, our results suggest that CoQ(10) supplementation may have beneficial effects during exercise.en_US
dc.description.sponsorshipScientific Research Foundation of Selcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipThis study is supported by the Scientific Research Foundation of Selcuk University.en_US
dc.identifier.doi10.1556/APhysiol.99.2012.1.5en_US
dc.identifier.endpage50en_US
dc.identifier.issn0231-424Xen_US
dc.identifier.issn1588-2683en_US
dc.identifier.issue1en_US
dc.identifier.pmid22425807en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage40en_US
dc.identifier.urihttps://dx.doi.org/10.1556/APhysiol.99.2012.1.5
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27995
dc.identifier.volume99en_US
dc.identifier.wosWOS:000301585200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAKADEMIAI KIADO ZRTen_US
dc.relation.ispartofACTA PHYSIOLOGICA HUNGARICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectaortaen_US
dc.subjectcoenzyme Q(10)en_US
dc.subjectcontractionsen_US
dc.subjectexerciseen_US
dc.titleEffects of treatment with coenzyme Q(10) on exercised rat aortaen_US
dc.typeArticleen_US

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