Enantioselective resolution of racemic flurbiprofen methyl ester by lipase encapsulated mercapto calix[4]arenes capped Fe3O4 nanoparticles

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dc.contributor.authorYildiz, Hasan
dc.contributor.authorOzyilmaz, Elif
dc.contributor.authorBhatti, Asif Ali
dc.contributor.authorYilmaz, Mustafa
dc.date.accessioned2020-03-26T19:41:42Z
dc.date.available2020-03-26T19:41:42Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis work presents the synthesis of new mercapto calix[4]arenes derivatives (4 and 5). These derivatives were capped on Fe3O4 magnetic nanoparticles and subsequently encapsulated with Candida rugosa through sol-gel method to furnish enc-4 and enc-5, respectively, to enhance catalytic activity and enantioselectivity of lipase for hydrolysis reaction of racemic flurbiprofen methyl ester. Catalytic activity and enantioselectivity of enc-4 and enc-5 were assayed at different pH and temperature conditions and it was found that the resultant encapsulated enzyme exhibited higher thermal and operational stabilities compared to the free lipase in which enc-5 showed the excellent rate of enantioselectivity (E = 176) for S-flurbiprofen better than free lipase (E = 137) at pH 7 and 35 A degrees C for 48 h. The time study shows that enantioselectivity reached the maximum value of E = 244 after 72 h. Catalytic activity of these materials was hardly affected by 20 and 23% after five usages of enc-4 and enc-5, respectively.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University (BAP)Selcuk Universityen_US
dc.description.sponsorshipWe would like to thank The Research Foundation of Selcuk University (BAP) for their financial support of this work.en_US
dc.identifier.doi10.1007/s00449-017-1779-xen_US
dc.identifier.endpage1196en_US
dc.identifier.issn1615-7591en_US
dc.identifier.issn1615-7605en_US
dc.identifier.issue8en_US
dc.identifier.pmid28488138en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1189en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00449-017-1779-x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35068
dc.identifier.volume40en_US
dc.identifier.wosWOS:000405490000005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofBIOPROCESS AND BIOSYSTEMS ENGINEERINGen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMercaptocalix[4]areneen_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectEnzyme activityen_US
dc.subjectEnantioselectivityen_US
dc.titleEnantioselective resolution of racemic flurbiprofen methyl ester by lipase encapsulated mercapto calix[4]arenes capped Fe3O4 nanoparticlesen_US
dc.typeArticleen_US

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