Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorUysal, Ahmet
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorMocan, Andrei
dc.contributor.authorMollica, Adriano
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorCustodio, Luisa
dc.date.accessioned2020-03-26T19:41:43Z
dc.date.available2020-03-26T19:41:43Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, Methanolic extracts of Euphorbia denticulata parts (flowers, leaf, stem, and mix of aerial parts) were assessed for a panoply of bioactivities. Inhibitory potential against key enzymes involved in diabetes (alpha-glucosidase and alpha-amylase), obesity (pancreatic lipase), neurodegenerative diseases (cholinesterases), and hyperpigmentation (tyrosinase) was evaluated. The antioxidant and antibacterial properties were also assessed. The total phenolic, flavonoid, and phytochemical profile were established using HPLC/DAD and molecular modelling studies on specific target compounds were performed in silico. The flower extract was found to be rich in phenolics and flavonoids, (60.11 +/- 1.40 mgGAE/g and 42.04 +/- 0.16 mgRE/g respectively), which tend to correlate with the high radical scavenging activity of this extract (120.34 +/- 3.33 mgTE/g and 165.42 +/- 2.16 mgTE/g for DPPH and ABTS respectively). Catechin, epicatechin, gallic acid, p-OH-Benzoic acid, rosmarinic acid, and epigallocatechin gallate, found in significant abundance in the extracts were assessed using molecular modelling with the aim to study their docking properties on a set of six enzymes used in this study. The extracts were moderately effective with MIC values ranging between 1.56 to 6.25 mg/ml, but potent growth inhibitors of MRSA strains. Results amassed herein can be used as a stimulus for further studies geared towards the development of novel phyto-pharmaceuticals. (C) 2016 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.biopha.2016.12.063en_US
dc.identifier.endpage36en_US
dc.identifier.issn0753-3322en_US
dc.identifier.issn1950-6007en_US
dc.identifier.pmid28040595en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.biopha.2016.12.063
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35085
dc.identifier.volume87en_US
dc.identifier.wosWOS:000395525600004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERen_US
dc.relation.ispartofBIOMEDICINE & PHARMACOTHERAPYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEuphorbia denticulataen_US
dc.subjectDiabetesen_US
dc.subjectMolecular dockingen_US
dc.subjectPolyphenolsen_US
dc.subjectPhyto-pharmaceuticalsen_US
dc.titleEuphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulationsen_US
dc.typeArticleen_US

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