Frequency of Recombinant and Nonrecombinant Products of Pericentric Inversion of Chromosome 1 in Sperm Nuclei of Carrier: by Fish Technique

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dc.contributor.authorYakut, Tahsin
dc.contributor.authorAcar, Hasan
dc.contributor.authorEgeli, Ünal
dc.contributor.authorKimya, Yalçın
dc.date.accessioned2020-03-26T16:45:47Z
dc.date.available2020-03-26T16:45:47Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMeiotic segregation products of carriers with pericentric inversion are very important for assessing the risk of unbalanced forms and appropriate genetic counseling. We investigated the incidence of recombinant and nonrecombinant products of chromosome 1 with pericentric inversion, in the sperm nuclei of the carrier by using triple color fluorescence in situ hybridization (FISH). The centromere specific and telomere specific probes for chromosome 1 were used. In the segregation analysis, 1,636 sperm nuclei were analyzed; 82.5% of the sperms were including normal or inverted chromosome 1, and the dup(p)/del(q) and del(p)/dup(q) recombinant products in sperm nuclei of our carrier were 8.7 and 7.3%, respectively. The number of recombinant products may be dependent on the formation of an inversion loop, which the number of the formation of chiasmata results in the different number of normal/balanced and recombinant products. The use of FISH, using different probe combination, in sperm nuclei has proved to be an accurate approach to determine the meiotic segregation patterns and could help to better establish a reproductive prognosis and genetic counseling. (C) 2003 Wiley-Liss, Inc.en_US
dc.identifier.citationYakut, T., Acar, H., Egeli, Ü., Kimya, Y., (2003). Frequency of Recombinant and Nonrecombinant Products of Pericentric Inversion of Chromosome 1 in Sperm Nuclei of Carrier: by Fish Technique. Molecular Reproduction and Development, 66(1), 67-71. Doi: 10.1002/mrd.10325
dc.identifier.doi10.1002/mrd.10325en_US
dc.identifier.endpage71en_US
dc.identifier.issn1040-452Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid12874801en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://dx.doi.org/10.1002/mrd.10325
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18481
dc.identifier.volume66en_US
dc.identifier.wosWOS:000184529700010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAcar, Hasan
dc.language.isoenen_US
dc.publisherWiley-Lissen_US
dc.relation.ispartofMolecular Reproduction and Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSperm-FISHen_US
dc.subjectPericentric inversionen_US
dc.subjectChromosome 1en_US
dc.subjectCarrieren_US
dc.titleFrequency of Recombinant and Nonrecombinant Products of Pericentric Inversion of Chromosome 1 in Sperm Nuclei of Carrier: by Fish Techniqueen_US
dc.typeArticleen_US

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