New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage - Salvia sclarea L.

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorŞenkardeş, İsmail
dc.contributor.authorMollica, Adriano
dc.contributor.authorPicot-Allain, Carene Marie Nancy
dc.contributor.authorBulut, Gizem
dc.contributor.authorDoğan, Ahmet
dc.contributor.authorMahomoodally, M. Fawzi
dc.date.accessioned2020-03-26T19:54:48Z
dc.date.available2020-03-26T19:54:48Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractSalvia sclarea L. is traditionally used to manage common human ailments and is consumed as a food product. This study aimed to establish the phytochemical profile and antioxidant potential of ethyl acetate, methanol, and water extracts of Salvia sclarea. The inhibitory action of the extracts against alpha-amylase, alpha-glucosidase, acetyicholinesterase, butyrylcholinesterase, and tyrosinase was also investigated. Methanol extract showed the highest phenolic and fiavonoid contents (81.78 mg GAE/g extract and 40.59 mg RE/g extract, respectively). Reversed phase high performance liquid chromatography with diode array detector analysis revealed that S. sclarea was rich in rosmarinic acid. The water extract exhibited the lowest inhibitory activity against alpha-amylase but the upmost activity against alpha-glucosidase (0.19 and 18.24 mmol ACAE/g extract, respectively). Experimental data showed that only the water extract (8.86 mg KAE/g extract) significantly inhibited tyrosinase. Docking studies showed that quercetin binds to tyrosinase by two hydrogen and a pi-pi bonds. Salvia sclarea showed interesting biological activity against key enzymes involved in the pathogenesis of common ailments. (C) 2018 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.compbiolchem.2018.05.005en_US
dc.identifier.endpage119en_US
dc.identifier.issn1476-9271en_US
dc.identifier.issn1476-928Xen_US
dc.identifier.pmid29772456en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.compbiolchem.2018.05.005
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36800
dc.identifier.volume75en_US
dc.identifier.wosWOS:000437057500013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofCOMPUTATIONAL BIOLOGY AND CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSalviaen_US
dc.subjectClary sageen_US
dc.subjectNatural enzyme inhibitorsen_US
dc.subjectMolecular dockingen_US
dc.titleNew insights into the in vitro biological effects, in silico docking and chemical profile of clary sage - Salvia sclarea L.en_US
dc.typeArticleen_US

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