Concentrations of sulfadoxine and trimethoprim in plasma, lymph fluids and some tissues 24 H after intramuscular administration to angora goats

Basit Öğe Kaydı
dc.contributor.authorTras, B
dc.contributor.authorElmas, M
dc.contributor.authorYazar, E
dc.contributor.authorBas, AL
dc.contributor.authorKeskin, E
dc.contributor.authorDasci, Z
dc.date.accessioned2020-03-26T16:26:06Z
dc.date.available2020-03-26T16:26:06Z
dc.date.issued1998
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study was carried out to determine the concentrations of sulfadoxine and trimethoprim in plasma, lymph, and some tissues in goats after administration of a single recommended therapeutic dose. Five healthy, adult Angora goats were used. The drug combination, containing 200 mg sulfadoxine and 40 mg trimethoprim per millilitre, was given as a single IM injection at the recommended dose level, 15 mg/kg body weight for sulfadoxine and 3 mg/kg body weight for trimethoprim. The goats were slaughtered 24 hours after drug administration and samples were taken from liver, bone marrow, pelvic limb muscles, hepatic, thoracic duct, and the pelvic limb lymph fluids for analysis of drug concentrations by HPLC. The concentrations of trimethoprim in bone marrow, liver, pelvic limb muscles, hepatic lymph, the pelvic limb lymph, and thoracic duct lymph were found to be 6, 5, 4, 2, 5 and 15 times higher than those of plasma, respectively. Although the sulfadoxine concentrations in bone marrow, pelvic limb muscles, and liver were 2, 3 and 2 times higher than the plasm concentrations, respectively, the sulfadoxine concentrations in hepatic lymph, the pelvic limb lymph, and thoracic duct lymph were lower than those of plasma. The results show that the trimethoprim concentrations in lymph fluids were quite similar to those in tissues. However, the sulfadoxine concentrations in lymph fluids were different in each tissue.en_US
dc.identifier.endpage64en_US
dc.identifier.issn0165-2176en_US
dc.identifier.issn1875-5941en_US
dc.identifier.issue2en_US
dc.identifier.pmid9563162en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16754
dc.identifier.volume20en_US
dc.identifier.wosWOS:000073026600005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofVETERINARY QUARTERLYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleConcentrations of sulfadoxine and trimethoprim in plasma, lymph fluids and some tissues 24 H after intramuscular administration to angora goatsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu