Effects of Oral L-Glutamine, Insulin and Laxative on Bacterial Translocation in Acute Pancreatitis

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dc.contributor.authorAvşar, Fatih Mehmet
dc.contributor.authorÖzel, İ. Hakan
dc.contributor.authorBaykan, Mahmut
dc.contributor.authorSaygun, Oral
dc.contributor.authorŞahin, Mustafa
dc.contributor.authorHengirmen, Süleyman
dc.contributor.authorErtuğrul, Ömür
dc.contributor.authorGürbilek, Mehmet
dc.contributor.authorAydın, S. Neşe
dc.date.accessioned2020-03-26T16:37:41Z
dc.date.available2020-03-26T16:37:41Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: To investigate the effects of oral L-glutamine, insulin and laxative on the bacterial population of intestinal lumen and on bacterial translocation in acute pancreatitis. Materials and Methods: Forty Sprague-Dawley adult male rats were divided into 4 groups. Experimental pancreatitis was induced by ligating the main biliopancreatic duct. All groups were given the standard rat diet and tap water. In addition. Group II was given. 15 mg/kg/day of L-glutamine via a catheter enterally, Group III was given 3 ml of laxative via a catheter enterally, and Group IV was given 3 IU/kg/day of NPH insulin via a catheter enterally. The rats were sacrificed 96 hours after the induction of pancreatitis. Blood samples for biochemical analyses and blood culture, and culture samples from mesenteric lymph nodes, liver and spleen and from cecal content were taken. Aerobic and anaerobic cultures were prepared. Findings: Amylase levels in all the groups after the procedure increased significantly. Bacterial translocation was observed in 6 rats in the control group, in 5 rats in the insulin group, in 3 rats in the laxative group and in 2 rats in the L-glutamine group. A significant decrease in the number of luminal bacteria was observed in the laxative and L-glutamine groups. Conclusion: L-glutamine, administered in enteral solutions in rats with induced acute pancreatitis, may reduce septic complications by decreasing the bacterial translocation rate. Similar effects are also produced by laxatives through reduction in the luminal bacterial population.en_US
dc.identifier.citationAvşar, F. M., Özel, İ. H., Baykan, M., Saygun, O., Şahin, M., Hengirmen, S., Ertuğrul, Ö., Gürbilek, M., Aydın, N. S., (2001). Effects of Oral L-Glutamine, Insulin and Laxative on Bacterial Translocation in Acute Pancreatitis. Turkish Journal of Medical Sciences, 31(4), 297-301.
dc.identifier.endpage301en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage297en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17678
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorŞahin, Mustafa
dc.institutionauthorErtuğrul, Ömür
dc.institutionauthorGürbilek, Mehmet
dc.institutionauthorBaykan, Mahmut
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcute pancreatitisen_US
dc.subjectBacterial translocationen_US
dc.subjectL-glutamineen_US
dc.subjectLaxativeen_US
dc.subjectOral insulinen_US
dc.subjectSepsisen_US
dc.titleEffects of Oral L-Glutamine, Insulin and Laxative on Bacterial Translocation in Acute Pancreatitisen_US
dc.typeArticleen_US

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