Bupivacaine and ropivacaine: Comparative effects on nerve conduction block

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dc.contributor.authorBariskaner, H.
dc.contributor.authorAyaz, M.
dc.contributor.authorGuney, F. B.
dc.contributor.authorDalkilic, N.
dc.contributor.authorGuney, O.
dc.date.accessioned2020-03-26T17:17:04Z
dc.date.available2020-03-26T17:17:04Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractUnlike other drugs which act in the region of the synapse, local anesthetics are agents that reversibly block the generation and conduction of nerve impulses along a nerve fiber. This study aims to investigate the comparative inhibitions of bupivacaine and ropivacaine on the frog sciatic nerve. Isolated nerves were transferred to the nerve chamber which includes Ringer's solution. The nerves were stimulated by), standard square wave pulse protocols and the responses were recorded with conventional systems. Bupivacaine (n = 8) and ropivacaine (n 8) were administered in the nerve chamber both with cumulative concentrations (10(-9) to 10(-3) M) and the effects were monitored for variable time periods (5. 10 and 15 min). Both bupivacaine and ropivacaine significantly depressed the compound action potential (CAP) parameters in a dose-dependent (p < 0.05) and reversible manner. Difference in the eftects of these two drugs was detectable only when the dose (>= 10(-5) M) and exposure time (15 min) were increased. Percent inhibitions in maximum derivatives and latency-period measurements have shown that ropivacaine is not only fast but also much more powerful in conduction block for longer and higher doses. Blipivacaine, on the other hand, is effective in the group of fibers with relatively slower conduction velocity for all the measured doses and time periods. In conclusion, ropivacaine has a sensory specific side of action, when compared with the bupivacaine. (c) 2007 Prous Science. All rights reserved.en_US
dc.identifier.doi10.1358/mf.2007.29.5.1117558en_US
dc.identifier.endpage341en_US
dc.identifier.issn0379-0355en_US
dc.identifier.issn2013-0155en_US
dc.identifier.issue5en_US
dc.identifier.pmid17805435en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage337en_US
dc.identifier.urihttps://dx.doi.org/10.1358/mf.2007.29.5.1117558
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21251
dc.identifier.volume29en_US
dc.identifier.wosWOS:000248996400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPROUS SCIENCE, SAU-THOMSON REUTERSen_US
dc.relation.ispartofMETHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbupivacaineen_US
dc.subjectcompound action potentialen_US
dc.subjectconduction velocityen_US
dc.subjectropivacaineen_US
dc.subjectsciatic nerveen_US
dc.titleBupivacaine and ropivacaine: Comparative effects on nerve conduction blocken_US
dc.typeArticleen_US

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