Peroperative effects of fresh frozen plasma and antithrombin III on heparin sensitivity and coagulation during nitroglycerine infusion in coronary artery bypass surgery

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dc.contributor.authorKanbak, Meral
dc.contributor.authorOc, Bahar
dc.contributor.authorSalman, Mehmet A.
dc.contributor.authorOcal, Turgay
dc.contributor.authorOc, Mehmet
dc.date.accessioned2020-03-26T18:15:36Z
dc.date.available2020-03-26T18:15:36Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractNitroglycerin (NTG) reduces the anticoagulant effects of heparin and may lead to heparin resistance. Fresh frozen plasma (FFP) and antithrombin III (ATIII) may be used for the treatment of heparin resistance. We aimed to compare the effects of FFP and ATIII on heparin requirement, coagulation parameters, and bleeding in patients undergoing coronary artery bypass graft surgery (CABGS) with moderate dose of intraoperative NTG infusion. Forty-eight patients undergoing CABGS with NTG infusion were randomly allocated to three groups. Group C served as control, whereas the patients in group P received FFP and those in group A received ATIII after anesthesia induction. ATIII activity and coagulation parameters were measured at five different times intraoperatively. Total heparin requirement, heparin consumption, and heparin sensitivity were calculated. ATIII activity and ACT were significantly higher and activated partial thromboplastin time and fibrinogen level were significantly lower during cardiopulmonary bypass in group A than in groups P and C. Heparin sensitivity was significantly higher and total heparin requirement and consumption were significantly lower in ATIII group than in other groups. ATIII administration increases heparin sensitivity and decreases heparin requirements compared with FFP in patients undergoing CABGS with peroperative NTG infusion. ATIII may be preferred to FFP in patients with heparin resistance due to NTG infusion undergoing CABGS. Blood Coagul Fibrinolysis 22:593-599 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.en_US
dc.identifier.doi10.1097/MBC.0b013e32834a0478en_US
dc.identifier.endpage599en_US
dc.identifier.issn0957-5235en_US
dc.identifier.issue7en_US
dc.identifier.pmid21799398en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage593en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MBC.0b013e32834a0478
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26713
dc.identifier.volume22en_US
dc.identifier.wosWOS:000295395800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofBLOOD COAGULATION & FIBRINOLYSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectantithrombin IIIen_US
dc.subjectblood coagulation testsen_US
dc.subjectcardiac surgeryen_US
dc.subjectfresh frozen plasmaen_US
dc.subjectheparinen_US
dc.subjectnitroglycerinen_US
dc.titlePeroperative effects of fresh frozen plasma and antithrombin III on heparin sensitivity and coagulation during nitroglycerine infusion in coronary artery bypass surgeryen_US
dc.typeArticleen_US

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