Effect of gamma-hydroxybutyric acid on lipid peroxidation and tissue lactate level in experimental head trauma
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Dosyalar
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
LIPPINCOTT WILLIAMS & WILKINS
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background. This study was designed to determine the effects of gammahydroxybutyric acid (GHB) on tissue lactate and malondialdehyde (MDA) levels in rabbit brain after experimental head trauma. Methods. Thirty New Zealand rabbits were divided equally into three groups: group S was the sham-operated group, group C, and group GHB received head trauma, where group C was the untreated and group GHB was the treated group. Head trauma was delivered by performing a craniectomy over the right hemisphere and dropping a weight of 10 g from a height of 80 cm. GHB was administered 400 mg/kg intravenously for 10 minutes after the head trauma to group GHB. The nontraumatized side was named "1" and the traumatized side was named "2." One hour after trauma, brain cortices were resected from both sides and the concentrations of lactate and MDA were determined. Results There were significant differences between lactate and MDA levels of group S and all other groups (C-1, C-2, GHB(1), and GHB(2)) except between lactate levels of group S and group GHB(1), the nontramnatized and traumatized sides of groups C and group GHB, group C-2 versus group GHB(2), and group C-1 versus group GHB(1) (p < 0.05). Rectal temperature after the administration of GHB in group GHB was found lower than in groups S and C (p < 0.05). Conclusion. These results demonstrate that head trauma leads to an increase in brain tissue lactate and MDA levels, and GHB effectively suppresses the increase of lactate and MDA.
Açıklama
Anahtar Kelimeler
gamma-hydroxybutyric acid, head trauma, lactate, malondialdehyde
Kaynak
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
56
Sayı
3
