Association of serum calcitonin with coronary artery disease in individuals with and without chronic kidney disease

dc.contributor.authorKanbay, Mehmet
dc.contributor.authorWolf, Myles
dc.contributor.authorSelcoki, Yusuf
dc.contributor.authorSolak, Yalcin
dc.contributor.authorIkizek, Mustafa
dc.contributor.authorUysal, Sema
dc.contributor.authorSegall, Liviu
dc.date.accessioned2020-03-26T18:24:01Z
dc.date.available2020-03-26T18:24:01Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD). Recent data implicate disordered bone and mineral metabolism, including changes in serum levels of calcium, phosphate, parathyroid hormone (PTH), vitamin D, fibroblast growth factor-23 (FGF-23), and fetuin A, as novel risk factors for arterial calcification. The potential role of calcitonin, another hormonal regulator of mineral and bone metabolism, has not been studied in detail. We investigated the link between serum calcitonin and the total burden of coronary artery disease (CAD) using the validated Gensini score, in a cross-sectional study of 88 patients with estimated GFR (eGFR) between 46 and 87 ml/min/1.73 mA(2) who underwent coronary angiography. We evaluated the associations between serum calcitonin, minerals (calcium, phosphate), calcium x phosphate product, and other factors that regulate mineral metabolism (intact PTH, 25-OH-vitamin D, FGF-23, and fetuin A) and the severity of CAD. The mean serum calcitonin was 11.5 +/- A 7.8 pg/ml. In univariate analysis, the Gensini CAD severity score correlated significantly with male gender, eGFR, and serum levels of 25-OH-vitamin D, iPTH, FGF-23, fetuin A, and calcitonin (R = 0.474, P = 0.001 for the latter). In multivariate analysis adjusted for calcium, phosphate, 25-OH-vitamin D, iPTH, FGF 23, fetuin A, and calcitonin, only calcitonin (beta = 0.20; P = 0.03), FGF-23, fetuin A, and 25-OH-vitamin D emerged as independent predictors of Gensini score. In the second step, we adjusted for the presence of traditional risk factors, proteinuria, and GFR. After these adjustments, the FGF-23 and fetuin A remained statistically significant predictors of the Gensini score, while calcitonin did not. Our study suggests that, in addition to other well-known components of mineral metabolism, increased calcitonin levels are associated with greater severity of CAD. However, this relation was not independent of traditional and nontraditional cardiovascular risk factors. Longitudinal studies in larger populations including patients with more advanced CKD are needed.en_US
dc.identifier.doi10.1007/s11255-011-0076-xen_US
dc.identifier.endpage1175en_US
dc.identifier.issn0301-1623en_US
dc.identifier.issue4en_US
dc.identifier.pmid22130958en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1169en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11255-011-0076-x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27773
dc.identifier.volume44en_US
dc.identifier.wosWOS:000306683200027en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofINTERNATIONAL UROLOGY AND NEPHROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCalcitoninen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectMineralen_US
dc.subjectBoneen_US
dc.titleAssociation of serum calcitonin with coronary artery disease in individuals with and without chronic kidney diseaseen_US
dc.typeArticleen_US

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