Management of Brucella Endocarditis: Results of the Gulhane Study

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dc.contributor.authorKoruk, Suda Tekin
dc.contributor.authorErdem, Hakan
dc.contributor.authorKoruk, İbrahim
dc.contributor.authorErbay, Ayşe
dc.contributor.authorTekce, Yasemin Tezer
dc.contributor.authorErbay, Ali Rıza
dc.contributor.authorDayan, Sami
dc.contributor.authorDeveci, Özcan
dc.contributor.authorİnan, Asuman
dc.contributor.authorEngin, Derya Öztürk
dc.contributor.authorGüner, Rahmet
dc.contributor.authorDikici, Nebahat
dc.contributor.authorKartal, Elif Doyuk
dc.contributor.authorKurtaran, Behice
dc.contributor.authorPehlivanoglu, Filiz
dc.contributor.authorSipahi, Oğuz Reşat
dc.contributor.authorYalcı, Asuman
dc.contributor.authorYemisen, Mücahit
dc.contributor.authorÇavus, Sema Alp
dc.contributor.authorGencer, Serap
dc.contributor.authorGüzel, Gökhan
dc.contributor.authorÖncül, Oral
dc.contributor.authorParlak, Mehmet
dc.contributor.authorKazak, Esra
dc.contributor.authorTülek, Necla
dc.contributor.authorUlcay, Asim
dc.contributor.authorSavaşçı, Ümit
dc.date.accessioned2020-03-26T18:30:50Z
dc.date.available2020-03-26T18:30:50Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBrucella endocarditis (BE) is a rare but life-threatening complication of human brucellosis. The aim of this study was to investigate the course of BE along with the therapeutic interrelations. A total of 53 patients with BE hospitalised in 19 health institutions between 2006 and 2011 were included in the Gulhane study. Diagnosis of brucellosis was established by either isolation of Brucella sp. or the presence of antibodies, and the definition of endocarditis was made according to Duke's criteria. There were four treatment groups: ceftriaxone combined with oral antibiotics (Group 1); aminoglycosides combined with oral antibiotics (Group 2); oral antibiotic combinations (Group 3); and aminoglycoside plus ceftriaxone combined with an oral antibiotic (Group 4). Involvement rates of the aortic, mitral and tricuspid valves were 49.1%, 43.4% and 5.7%, respectively. Thirty-two patients (60.4%) had an underlying cardiac valvular problem, including previous prosthetic valve replacement (n = 18). Medical treatment was provided to 32 patients (60.4%), whilst concordant medical and surgical approaches were provided to 21 patients (39.6%). Mortality in Group 1 was 15% (3/20), whilst in Group 2 it was 5.3% (1/19). In Group 3, 25.0% (3/12) of the cases died, whereas none of the cases in Group 4 died. In conclusion, mortality increased 47-fold with pericardial effusion and 25-fold due to congestive heart failure that developed after BE. Although mortality was lower in the aminoglycoside-containing arm (Groups 2 and 4), statistical analysis could not be performed owing to the small number of patients.en_US
dc.identifier.citationKoruk, S. T., Erdem, H., Koruk, İ., Erbay, A., Tezer Tekce, Y., Erbay, A. R., Dayan, S., Deveci, Ö., İnan, A., Engin, D. Ö., Güner, R., Dikici, N., Doyuk Kartal, E., Kurtaran, B., Pehlivanoglu, F., Sipahi, O. R., Yalci, A., Yemisen, M., Alp Çavus, S., Gencer, S., Güzel, G., Öncül, O., Parlak, M., Kazak, E., Tülek, N., Ulcay, A., Savaşçı, Ü., (2012). Management of Brucella Endocarditis: Results of the Gulhane Study. International Journal of Antimicrobial Agents, 40(2), 145-150. doi: 10.1016/j.ijantimicag.2012.04.009
dc.identifier.doi10.1016/j.ijantimicag.2012.04.009en_US
dc.identifier.endpage150en_US
dc.identifier.issn0924-8579en_US
dc.identifier.issue2en_US
dc.identifier.pmid22727531en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijantimicag.2012.04.009
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28211
dc.identifier.volume40en_US
dc.identifier.wosWOS:000306663800009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDikici, Nebahat
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofInternational Journal of Antimicrobial Agentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBrucellosisen_US
dc.subjectEndocarditisen_US
dc.subjectTherapyen_US
dc.subjectMortalityen_US
dc.titleManagement of Brucella Endocarditis: Results of the Gulhane Studyen_US
dc.typeArticleen_US

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