Using Computerized Cytomorphometry to Distinguish between Benign and Malignant Cases in Thyroid Fine-Needle Aspiration Cytology

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dc.contributor.authorÇelik, Zeliha Esin
dc.contributor.authorAltınay, Serdar
dc.contributor.authorKılınç, Fahriye
dc.contributor.authorArslan, Nur
dc.contributor.authorYılmaz, Burcu Sanal
dc.contributor.authorKarabağlı, Pınar
dc.contributor.authorUğurluoğlu, Ceyhan
dc.date.accessioned2020-03-26T19:31:49Z
dc.date.available2020-03-26T19:31:49Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackgroundOnly a small number of studies on computerized cytomorphometry have been performed for thyroid FNAC. The present study aimed to determine the usefulness of computerized cytomorphometry methods to further classify thyroid lesions as benign or malignant and to compare the practicability and value of using Papanicolaou (Pap) and Giemsa stains in thyroid FNAC by evaluating their association to various cytologic nuclear parameters. MethodsFifty-eight thyroid lesions diagnosed by FNAC and categorized according to the Bethesda system for reporting thyroid cytopathology were evaluated in terms of various cytologic nuclear parameters, including nuclear area (NA), nuclear perimeter (NP), nuclear density (ND), long nuclear diameter (LND), and short nuclear diameter (SND). The Pap- and Giemsa-stained slides were examined separately. ResultsIn the malignant cases, NA, NP, LND, and SND were higher than in the benign cases for both the Pap and Giemsa stains. NA, NP, LND, and SND were higher in Giemsa than Pap for both the benign and malignant groups. Statistically significant differences were detected between the benign and malignant cases in the AUS category. ConclusionsComputerized cytomorphometry is useful in distinguishing between benign and malignant lesions in thyroid FNAC. The measurement of cytologic nuclear parameters in cases suggestive of AUS may be useful for the probable classification of cases as benign or malignant. Although further studies are needed, in nuclear morphometric assessment of thyroid FNAC, Giemsa staining may be more useful and valuable than the Pap stain because of its association with various cytologic nuclear parameters. Diagn. Cytopathol. 2016;44:902-911. (c) 2016 Wiley Periodicals, Inc.en_US
dc.identifier.doi10.1002/dc.23611en_US
dc.identifier.endpage911en_US
dc.identifier.issn8755-1039en_US
dc.identifier.issn1097-0339en_US
dc.identifier.issue11en_US
dc.identifier.pmid27629534en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage902en_US
dc.identifier.urihttps://dx.doi.org/10.1002/dc.23611
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34185
dc.identifier.volume44en_US
dc.identifier.wosWOS:000385757200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofDIAGNOSTIC CYTOPATHOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcytomorphometryen_US
dc.subjectthyroid FNACen_US
dc.subjectatypia of undetermined significanceen_US
dc.subjectGiemsaen_US
dc.subjectPapanicolaouen_US
dc.titleUsing Computerized Cytomorphometry to Distinguish between Benign and Malignant Cases in Thyroid Fine-Needle Aspiration Cytologyen_US
dc.typeArticleen_US

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