Low Risk of Severe Hypoglycaemia in Patients With Type 2 Diabetes Mellitus Starting Insulin Therapy With Premixed Insulin Analogues Bid in Outpatient Settings

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dc.contributor.authorPirags, V.
dc.contributor.authorEl Damassy, H.
dc.contributor.authorDabrowski, M.
dc.contributor.authorGönen, M. S.
dc.contributor.authorRacicka, E.
dc.contributor.authorMartinka, E.
dc.contributor.authorGiaconia, J.
dc.contributor.authorStefanski A.
dc.date.accessioned2020-03-26T18:30:49Z
dc.date.available2020-03-26T18:30:49Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAims: The choice of insulin at initiation in type 2 diabetes remains controversial. The aim of this study was to assess the occurrence of self-reported severe hypoglycaemia associated with premixed insulin analogues in routine clinical care. Methods: A 12-month, prospective, observational, multicentre study in patients starting a commonly prescribed premixed insulin analogue (either insulin lispro 25/75 or biphasic insulin aspart 30/70, twice daily) after suboptimal glycaemic control on oral antidiabetic agents. Treatment decisions were made solely in the course of usual practice. Results: Study follow-up was completed by 991 (85.5%) of the 1150 patients enrolled. At baseline, mean (SD) age was 57.9 (10.1) years; mean diabetes duration was 9.2 (5.9) years; mean haemoglobin A1c (HbA1c) was 9.9 (1.8) % and the rate of severe hypoglycaemia was 0.03 episode/patient-year. At 12 months, the rate of severe hypoglycaemia was 0.04 episode/patient-year (95% CI 0.023, 0.055 episode/patient-year) and mean insulin dose was 41.5 (19.4) units. Changes from baseline to 12 months for mean fasting plasma glucose and HbA1c were -5.1 mmol/l and -2.5%, respectively. Conclusions: After initiation of premixed insulin analogues in patients with type 2 diabetes in real-world settings, the incidence of severe hypoglycaemia was lower than expected from previously reported studies.en_US
dc.description.sponsorshipEli Lilly and CompanyEli Lillyen_US
dc.description.sponsorshipThis study was supported by Eli Lilly and Company. The following employees of Eli Lilly and Company were involved: Jacek Kiljanski, MD, for study design; Helmut Petto, MSc, for study design, analysis planning and implementation; Matthew Reaney, MSc, for data interpretation and Simon Cleall, MSc, for data interpretation. The authors thank the study investigators, who are listed in the Appendix.en_US
dc.identifier.citationPirags, V., El Damassy, H., Dabrowski, M., Gonen, M. S., Racicka, E., Martinka, E., Giaconia, J., Stefanski A., (2012). Low Risk of Severe Hypoglycaemia in Patients With Type 2 Diabetes Mellitus Starting Insulin Therapy With Premixed Insulin Analogues Bid in Outpatient Settings. International Journal of Clinical Practice, 66(11), 1033-1041. Doi: 10.1111/j.1742 1241.2012.03001.x
dc.identifier.doi10.1111/j.1742-1241.2012.03001.xen_US
dc.identifier.endpage1041en_US
dc.identifier.issn1368-5031en_US
dc.identifier.issn1742-1241en_US
dc.identifier.issue11en_US
dc.identifier.pmid23067027en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1033en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1742-1241.2012.03001.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28201
dc.identifier.volume66en_US
dc.identifier.wosWOS:000310265500005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGönen, M. S.
dc.language.isoenen_US
dc.publisherWıleyen_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleLow Risk of Severe Hypoglycaemia in Patients With Type 2 Diabetes Mellitus Starting Insulin Therapy With Premixed Insulin Analogues Bid in Outpatient Settingsen_US
dc.typeArticleen_US

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