Correlation of Tissue Selectin Expression and Hemodynamic Parameters in Rheumatic Mitral Valve Disease

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dc.contributor.authorTokgözoğlu, Lale
dc.contributor.authorCan, İlknur
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorAsan, Esin
dc.contributor.authorÖzer, Necla
dc.contributor.authorDemircin, Metin
dc.date.accessioned2020-03-26T17:03:17Z
dc.date.available2020-03-26T17:03:17Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description27th Congress of the European-Society-of-Cardiology -- SEP 03-07, 2005 -- Stockholm, SWEDENen_US
dc.description.abstractBackground and aim of the study: The study aim was to examine tissue expression of the adhesion molecules E-selectin and P-selectin on atrial, valvular and atrial myocardial blood vessel endothelium in patients with rheumatic mitral stenosis, and to investigate whether such expression was correlated with hemodynamics. Methods: Thirteen patients (eight women, five men; mean age 51 10 years) with severe rheumatic mitral stenosis who underwent mitral valve replacement surgery were examined on preoperative day 1, using cardiac catheterization and echocardiography. Specimens from the mitral valve and left atrium of each patient were evaluated for CD 62E and CD 62P expression using indirect immunoperoxidase and immunofluorescence techniques Results: A great majority of patients presented E and/or P selectin expression of variable intensity on atrial, valvular and atrial myocardial blood vessel endothelium. A more diffuse and stronger reaction for CD 62P was noted compared to that for CD 62E. The left ventricular end-diastolic diameter and left atrial diameter were positively correlated with endocardial. CD 62P and CD 62E expression. Right atrial pressure was also strongly and positively correlated with endocardial expression of CD 62E (r = 0.80, p = 0.03) and CD 62P (r = 0.8, p = 0.02). Conclusion: Marked tissue expression of CD 62E and CD 62P was identified on atrial, valvular and atrial myocardial blood vessel endothelium. Moreover, the degree of expression of adhesion molecules was significantly correlated with the left atrial and left ventricular chamber diameters, as well as right atrial pressure.en_US
dc.description.sponsorshipEuropean Soc Cardiolen_US
dc.identifier.citationTokgözoğlu, L., Can, İ., Korkusuz, P., Asan, E., Özer, N., Demircin, M., (2006). Correlation of Tissue Selectin Expression and Hemodynamic Parameters in Rheumatic Mitral Valve Disease. Journal of Heart Valve Disease, 15(5), 671-678.
dc.identifier.endpage678en_US
dc.identifier.issn0966-8519en_US
dc.identifier.issue5en_US
dc.identifier.pmid17044373en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage671en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20412
dc.identifier.volume15en_US
dc.identifier.wosWOS:000240581900014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI C R Publishersen_US
dc.relation.ispartofJournal of Heart Valve Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleCorrelation of Tissue Selectin Expression and Hemodynamic Parameters in Rheumatic Mitral Valve Diseaseen_US
dc.typeArticleen_US

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