Protective Effects of Caffeic Acid Phenethyl Ester on Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats

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dc.contributor.authorUysal, Ersin
dc.contributor.authorYılmaz, H. Ramazan
dc.contributor.authorUgan, Yunus
dc.contributor.authorAltuntaş, Atila
dc.contributor.authorDoğru, Atalay
dc.contributor.authorKutlucan, Ali
dc.contributor.authorTunç, Şevket Ercan
dc.date.accessioned2020-03-26T19:06:48Z
dc.date.available2020-03-26T19:06:48Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe investigated the protective effect of caffeic acid phenethyl ester (CAPE) on cyclophosphamide-induced hemorrhagic cystitis in rats in comparison with 2-mercaptoethane sulfonate (MESNA). Forty male rats were randomized into four groups: group 1 (control), group 2 (cyclophosphamide), group 3 (cyclophosphamide + MESNA), group 4 (cyclophosphamide + CAPE). Cyclophosphamide injection increased malondialdehyde levels indicating oxidative stress, whereas CAPE and MESNA ameliorated malondialdehyde levels in the bladder (p < 0.05). Only catalase activities were decreased significantly in both groups (cyclophosphamide + MESNA and cyclophosphamide + CAPE, p < 0.05). Pretreatment with CAPE (p < 0.01) resulted in a significant decrease in nitric oxide levels when compared with the cyclophosphamide group. When we consider the studies that show the critical importance of increased nitric oxide levels in pathogenesis of cyclophosphamide-induced hemorrhagic cystitis, we suggest that it would be more beneficial to use MESNA with CAPE to prevent histological damage. (C) 2015 Wiley Periodicals, Inc.en_US
dc.description.sponsorshipSuleyman Demirel University Coordination Unit of Scientific Research ProjectSuleyman Demirel Universityen_US
dc.description.sponsorshipThis study was supported by the Suleyman Demirel University Coordination Unit of Scientific Research Project. The authors declare that there are no conflicts of interest.en_US
dc.identifier.doi10.1002/jbt.21728en_US
dc.identifier.endpage563en_US
dc.identifier.issn1095-6670en_US
dc.identifier.issn1099-0461en_US
dc.identifier.issue12en_US
dc.identifier.pmid26207616en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage559en_US
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.21728
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32474
dc.identifier.volume29en_US
dc.identifier.wosWOS:000367688500003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofJOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectCyclophosphamideen_US
dc.subjectHemorrhagic Cystitisen_US
dc.subject2-Mercaptoethane Sulfonateen_US
dc.titleProtective Effects of Caffeic Acid Phenethyl Ester on Cyclophosphamide-Induced Hemorrhagic Cystitis in Ratsen_US
dc.typeArticleen_US

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