A Randomized Study of Allopurinol on Endothelial Function and Estimated Glomular Filtration Rate in Asymptomatic Hyperuricemic Subjects with Normal Renal Function

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dc.contributor.authorKanbay, Mehmet
dc.contributor.authorHuddam, Bulent
dc.contributor.authorAzak, Alper
dc.contributor.authorSolak, Yalcin
dc.contributor.authorKadioglu, Gulay Kocak
dc.contributor.authorKirbas, Ismail
dc.contributor.authorDuranay, Murat
dc.date.accessioned2020-03-26T18:13:41Z
dc.date.available2020-03-26T18:13:41Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and objectives Endothelial dysfunction is an early manifestation of vascular injury and contributes to the development of atherosclerotic cardiovascular disease. Recent studies have implicated hyperuricemia as a risk factor for cardiovascular disease. We hypothesized that lowering uric acid in subjects with asymptomatic hyperuricemia with allopurinol might improve endothelial dysfunction, BP, estimated GFR (eGFR), and inflammatory markers. Design, setting, participants, & measurements Subjects with asymptomatic hyperuricemia and no history of gout and 30 normouricemic control subjects were enrolled in this 4-month randomized prospective study. Thirty hyperuricemic patients received 300 mg/d allopurinol and were compared with 37 hyperuricemic patients and 30 normouricemic subjects in matched control groups. Flow-mediated dilation (FMD), eGFR, ambulatory BP monitoring, spot urine protein-creatine ratio, and highly sensitive C-reactive protein were measured at baseline and at 4 months. Results Age, gender, lipid profile, eGFR, hemoglobin, glucose, and level of proteinuria were similar in hyperuricemic subjects and controls at baseline. As expected, hyperuricemic patients had higher levels of highly sensitive C-reactive protein and lower FMD compared with normouricemic patients. Allopurinol treatment resulted in a decrease in serum uric acid, a decrease in systolic BP, an increase in FMD, and an increase in eGFR compared with baseline. No significant difference was observed in the control hyperuricemic and normouricemic groups. In a multiple regression analysis, FMD levels were independently related to uric acid both before (beta = -0.55) and after (beta = -0.40) treatment. Conclusions Treatment of hyperuricemia with allopurinol improves endothelial dysfunction and eGFR in subjects with asymptomatic hyperuricemia. Clin J Am Soc Nephrol 6: 1887-1894, 2011. doi: 10.2215/CJN.11451210en_US
dc.identifier.doi10.2215/CJN.11451210en_US
dc.identifier.endpage1894en_US
dc.identifier.issn1555-9041en_US
dc.identifier.issn1555-905Xen_US
dc.identifier.issue8en_US
dc.identifier.pmid21784838en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1887en_US
dc.identifier.urihttps://dx.doi.org/10.2215/CJN.11451210
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26070
dc.identifier.volume6en_US
dc.identifier.wosWOS:000293721400015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAMER SOC NEPHROLOGYen_US
dc.relation.ispartofCLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleA Randomized Study of Allopurinol on Endothelial Function and Estimated Glomular Filtration Rate in Asymptomatic Hyperuricemic Subjects with Normal Renal Functionen_US
dc.typeArticleen_US

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