Crocus Sativus, Serenoa Repens and Pinus Massoniana Extracts Modulate Inflammatory Response in Isolated Rat Prostate Challenged with LPS

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dc.authorid0000-0002-8901-6484
dc.contributor.authorChiavaroli, Annalisa
dc.contributor.authorRecinella, Lucia
dc.contributor.authorFerrante, Claudio
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorCarradori, Simone
dc.contributor.authorMacchione, Nicola
dc.contributor.authorZengin, Gökhan
dc.contributor.authorLeporini, Lidia
dc.contributor.authorLeone, Sheila
dc.contributor.authorMartinotti, S.
dc.contributor.authorBrunetti, L.
dc.contributor.authorVacca, M.
dc.contributor.authorMenghini, Luigi
dc.contributor.authorOrlando, Giulia
dc.date.accessioned2020-03-26T19:34:41Z
dc.date.available2020-03-26T19:34:41Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümü
dc.description.abstractProstatitis is a common prostate disease that could be promoted by bacterial or non-bacterial infectious agents. In addition, inflammatory pathways involved in prostatitis have been increasingly studied, and herbal extracts endowed with anti-inflammatory effects are under investigation, individually or in combination, for their efficacy in alleviating the burden of inflammation, with possible improvements in symptoms. Serenoa repens (Serenoa), in combination with Crocus sativus (Crocus) and Pinus massoniana (Pinus), has previously shown to improve sexual function and limit urinary symptoms in patients suffering from concomitant erectile dysfunction and lower urinary tract symptoms. In this context, the aim of the present study is to evaluate the efficacy of Serenoa, Crocus and Pinus extracts, either alone or in combination, on immortalized prostate cells (PC3) and in an experimental model of bacterial prostatitis constituted by ex vivo prostate specimens challenged with lipopolysaccharide (LPS). We found that the tested extracts were able to reduce ROS production by PC3 cells and NF kappa B and PGE(2) activity in prostate specimens challenged with LPS. In addition, the pharmacological association of the extracts displayed synergistic effects indicating a rational use of the mixture of the tested extracts as a novel anti-oxidant and anti-inflammatory formulation in bacterial prostatitis. Finally, we performed analytical and in vitro evaluation to better characterize the phytochemical profile and the mechanism of action of selected secondary metabolites.en_US
dc.description.sponsorshipItalian Ministry of Universities [FAR 2016]en_US
dc.description.sponsorshipThis work was supported by grants from the Italian Ministry of Universities (FAR 2016).en_US
dc.identifier.endpage541en_US
dc.identifier.issn0393-974Xen_US
dc.identifier.issn1724-6083en_US
dc.identifier.issue3en_US
dc.identifier.pmid28889734en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage531en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34937
dc.identifier.volume31en_US
dc.identifier.wosWOS:000412687500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherBIOLIFE SASen_US
dc.relation.ispartofJournal of Biological Regulators and Homeostatic Agentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSerenoa repensen_US
dc.subjectPinus massoniana Lamb.en_US
dc.subjectCrocus sativus L.en_US
dc.subjectPGE(2)en_US
dc.subjectNF kappa Ben_US
dc.subjectROSen_US
dc.subjectViabilityen_US
dc.titleCrocus Sativus, Serenoa Repens and Pinus Massoniana Extracts Modulate Inflammatory Response in Isolated Rat Prostate Challenged with LPSen_US
dc.typeArticleen_US

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