Effectiveness of corticosteroids in otitis media with effusion: an experimental study

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dc.contributor.authorYaman, H.
dc.contributor.authorOzturk, K.
dc.contributor.authorUyar, Y.
dc.contributor.authorGurbilek, M.
dc.date.accessioned2020-03-26T17:26:44Z
dc.date.available2020-03-26T17:26:44Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The aim of the present study was to investigate the dose-related effectiveness of corticosteroids in the management of otitis media with effusion, by using the objective assessment techniques of tympanometry and cytokine measurement. Materials and methods: The eustachian tubes of 42 male rats were obstructed. Thirty-six subjects with effusion were randomly divided into three equal groups: controls; 0.5 mg/kg/day corticosteroid; and 1 mg/kg/day corticosteroid. Concentrations of interleukin-1 beta and tumour necrosis factor a in the middle-ear effusions were analysed using enzyme-linked immunosorbent assay. Results: An effusion occurred on the 14th post-operative day and was present on the 30th post-operative day in the control group. Otomicroscopic examination and tympanometric measurement showed an improvement in the intervention groups. There was a significant difference between both intervention groups and the control group for both interleukin-1 beta and tumour necrosis factor alpha concentrations (p < 0.01). However, there was no significant difference between the 0.5 mg/kg and the I mg/kg corticosteroid groups (p > 0.05). Conclusion: The study confirmed a short term beneficial effect of systemic steroids on resolution of otitis media with effusion in a rat model. Our results support the theory that corticosteroids significantly decrease concentrations of both interleukin-1 beta and tumour necrosis factor alpha. In our model, the 0.5 mg/kg corticosteroid dose was as effective as the 1 mg/kg corticosteroid dose. Further studies should be carried out to determine the optimal dose and duration of corticosteroids in the treatment of otitis media with effusion.en_US
dc.identifier.doi10.1017/S0022215107007724en_US
dc.identifier.endpage30en_US
dc.identifier.issn0022-2151en_US
dc.identifier.issue1en_US
dc.identifier.pmid17445334en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://dx.doi.org/10.1017/S0022215107007724
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22351
dc.identifier.volume122en_US
dc.identifier.wosWOS:000252864600006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCAMBRIDGE UNIV PRESSen_US
dc.relation.ispartofJOURNAL OF LARYNGOLOGY AND OTOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectotitis media with effusionen_US
dc.subjectacoustic impedence testsen_US
dc.subjecttumour necrosis factor-alphaen_US
dc.subjectinterleukinesen_US
dc.subjectcorticosteroidsen_US
dc.titleEffectiveness of corticosteroids in otitis media with effusion: an experimental studyen_US
dc.typeArticleen_US

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