Corynebacterium cutis Lysate Treatment Can Increase the Efficacies of PPR Vaccine

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dc.contributor.authorDik, Burak
dc.contributor.authorDik, Irmak
dc.contributor.authorBahcivan, Emre
dc.contributor.authorAvci, Oguzhan
dc.date.accessioned2020-03-26T19:23:29Z
dc.date.available2020-03-26T19:23:29Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study aimed to evaluate the effects of Peste des petits ruminants (PPR) vaccine on cytokine and antibody levels in sheep when administered alone or in combination with Corynebacterium cutis lysate (CCL). The PPR vaccine group received a single subcutaneous axillary injection of the PPR vaccine (1mL containing tissue culture infectious dose (TCID)(50) attenuated live PPRV, n=6) and the combination treatment (1mL CCL and 1mL PPR vaccine, n=6) groups received a single subcutaneous axillary injection of both CCL and PPR vaccine. Blood samples were collected from sheep before the treatment and at different points after treatment (1, 3, 7, 14, 21, and 28 days). Plasma and serum samples were evaluated for antibody percentage, levels of cytokines IL-6, IL-10, IFN-, IL-4, IL-12, and IL-18, oxidative stress marker Thiobarbituric acid reactive substances, and hematological and biochemical parameters. Maximum protective antibody levels reach 3-4 weeks after vaccine administration. The combination treatment resulted in significant changes in IFN-, IL-4, IL-12, and IL-18 cytokine levels. These changes were not evident when only the PPR vaccine was administered and antibody percentage against PPRV was short term in PPR vaccine group. In conclusion, combined usage of the PPR vaccine with CCL resulted in a heightened cytokine response, leading to improved antibody level against PPR virus. Repeated CCL treatments can lead to earlier vaccine potency, provide protective efficacy for a longer time, and increase passive immunity.en_US
dc.description.sponsorshipSUPABK [15401153]en_US
dc.description.sponsorshipThis study is supported by SUPABK (15401153). A part of the abstract will be presented at the 6th European Congress of Virology (ECV), Hamburg, Germany and the other part of the abstract was presented at the 18th International Conference on Laboratory Medicine and Clinical Research, Amsterdam, the Netherlands.en_US
dc.identifier.doi10.1089/jir.2016.0035en_US
dc.identifier.endpage606en_US
dc.identifier.issn1079-9907en_US
dc.identifier.issn1557-7465en_US
dc.identifier.issue10en_US
dc.identifier.pmid27533481en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage599en_US
dc.identifier.urihttps://dx.doi.org/10.1089/jir.2016.0035
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33407
dc.identifier.volume36en_US
dc.identifier.wosWOS:000385654900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMARY ANN LIEBERT, INCen_US
dc.relation.ispartofJOURNAL OF INTERFERON AND CYTOKINE RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectpeste des petits ruminantsen_US
dc.subjectCorynebacterium cutis lysateen_US
dc.subjectcytokineen_US
dc.subjectinterferonen_US
dc.subjectvaccine effectivenessen_US
dc.titleCorynebacterium cutis Lysate Treatment Can Increase the Efficacies of PPR Vaccineen_US
dc.typeArticleen_US

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