Association of Serum Reactive Oxygen Metabolite Levels With Different Histopathological Types of Lung Cancer

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dc.contributor.authorGencer, Mehmet
dc.contributor.authorCeylan, Erkan
dc.contributor.authorAksoy, Nurten
dc.contributor.authorUzun, Kürşat
dc.date.accessioned2020-03-26T17:03:06Z
dc.date.available2020-03-26T17:03:06Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Oxygen is required for respiration and the energetic processes that enable aerobic life. Costs associated with oxygen use are free radical and reactive oxygen metabolite ( ROM) formations, which create oxidative stress and contribute to various processes including aging, degenerative diseases and cancer. Additionally, they may have a role in the pathogenesis of lung cancer with different histopathological types. Objectives: In this study, we aimed to investigate the degree of oxidative stress in different types of carcinoma such as small cell carcinoma and non-small cell carcinoma, including epidermoid carcinoma and adenocarcinoma, and to find out whether the degree of oxidative stress shows any difference among them and whether it can be used as an index for their differential diagnosis. Methods: Thirty-eight patients with lung cancer and 26 healthy persons were included in the study. Of the patients with lung cancer, 14 had epidermoid carcinoma, 12 adenocarcinoma and 12 small cell carcinoma. Serum ROM levels were detected by using an available commercial kit according to the manufacturer's instructions. Results: The ROM levels were significantly lower in the controls than in the patients ( p < 0.001). Although all subtypes had significantly high ROM levels compared with the controls, the highest significance was found in the small cell carcinoma ( p < 0.001), and then in the adenocarcinoma and epidermoid carcinoma ( p < 0.01 and p < 0.01, respectively). Conclusions: In the light of these data, it might be possible to conclude that the serum ROM levels increase in patients with different types of lung cancers and may be an index parameter for lung cancer. It could be thought that this increase, particularly in small cell carcinoma, may contribute to its poor progression.en_US
dc.identifier.citationUzun, K., Aksoy, N., Ceylan, E., Gencer, M., (2006). Association of Serum Reactive Oxygen Metabolite Levels With Different Histopathological Types of Lung Cancer. Respiration, (73), 520-524. Doi: 10.1159/000088895
dc.identifier.doi10.1159/000088895en_US
dc.identifier.endpage524en_US
dc.identifier.issn0025-7931en_US
dc.identifier.pmid16432293en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage520en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000088895
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20346
dc.identifier.volume73en_US
dc.identifier.wosWOS:000241775500020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUzun, Kürşat
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofRespirationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectlung canceren_US
dc.subjectsmall cell carcinomaen_US
dc.subjectadenocarcinomaen_US
dc.subjectepidermoid carcinomaen_US
dc.subjectoxidative stressen_US
dc.subjectreactive oxygen metaboliteen_US
dc.titleAssociation of Serum Reactive Oxygen Metabolite Levels With Different Histopathological Types of Lung Canceren_US
dc.typeArticleen_US

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