Effects of cooling and warming on 5-hydroxytryptamine- and acetylcholine-induced contractions of human umbilical vessels: role of nitric oxide

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dc.contributor.authorAtalık, Kısmet Esra Nurullahoğlu
dc.contributor.authorKılıç, M.
dc.contributor.authorNurullahoğlu, Zahide Ülya
dc.contributor.authorDogan, N.
dc.date.accessioned2020-03-26T17:26:45Z
dc.date.available2020-03-26T17:26:45Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effects of cooling (to 28 degrees C) and warming (to 41 degrees C) on the vasoconstrictions induced by 5-hydroxytryptamine (5-HT) and acetylcholine (ACh) and the role of nitric oxide in these effects were analyzed in human umbilical artery and vein. 5-HT (10(-9)-10(-4) M) and ACh (10(-9)-10(-4) M) induced concentration-dependent contractions at 37, 28 and 41 degrees C. During cooling, the sensitivity, but not the maximal response, of 5-HT and ACh was significantly higher than at 37 degrees C; and during warming, again the sensitivity, but not the maximal response, of both contractile agents was significantly lower than at 37 degrees C. Neither cooling to 28 degrees C nor warming to 41 degrees C, after treatment with N(G)-nitro-L-arginine methyl esther (L-NAME, 10(-4) M), modify the effect of temperature in both vessels. These results suggest that cooling- and warming-induced responses in human umbilical artery and vein are independent of nitric oxide.en_US
dc.identifier.doi10.1111/j.1472-8206.2007.00562.xen_US
dc.identifier.endpage44en_US
dc.identifier.issn0767-3981en_US
dc.identifier.issue1en_US
dc.identifier.pmid18251720en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1472-8206.2007.00562.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22355
dc.identifier.volume22en_US
dc.identifier.wosWOS:000252774300004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELL PUBLISHING, INCen_US
dc.relation.ispartofFUNDAMENTAL & CLINICAL PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcontractionsen_US
dc.subjectcoolingen_US
dc.subjectnitric oxideen_US
dc.subjectumbilical artery and veinen_US
dc.subjectwarmingen_US
dc.titleEffects of cooling and warming on 5-hydroxytryptamine- and acetylcholine-induced contractions of human umbilical vessels: role of nitric oxideen_US
dc.typeArticleen_US

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