Relation of in utero lead exposure with insulin-like growth factor-I levels and neonatal anthropometric parameters

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dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorKurtoglu, Selim
dc.contributor.authorPirgon, Ozgur
dc.contributor.authorUzum, Kazim
dc.contributor.authorSaraymen, Recep
dc.date.accessioned2020-03-26T17:18:03Z
dc.date.available2020-03-26T17:18:03Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOur aim was to establish whether independent relationships exist between either anthropometric parameters or insulin-like growth factor-I (IGF-I) and cord blood lead levels in newborns. Umbilical cord blood samples and anthropometric data were obtained at delivery. Cord blood lead levels were analyzed by atomic absorption spectrophotometer. IGF-I levels were measured using RIA. Blood lead levels >= 100 mu g/l were considered elevated in accordance with CDC guidelines. Data on all variables of interest were obtained for 54 term neonates. The mean cord blood lead level was 144 +/- 89 mu g/l with a range of 51-355 mu g/l. Twenty-nine (53.7%) neonates had blood lead levels >= 100 mu g/l. However, only 5 (9.2%) of the neonates had blood lead levels of >= 250 mu g/l. No statistically significant difference was found in case of anthropometric parameters and IGF-I levels between neonates with high lead levels (>= 100 mu g/l) and with low lead levels (< 100 mu g/l) in cord blood (p > 0.05). There was a significant correlation between lead and birth weight in neonates with high lead levels (r: -0.49, p = 0.01) but not other anthropometric data and IGF-I levels. A multivariate regression analysis using the full range of lead values adjusted for the relevant confounders such as gestational age and socioeconomic status was performed. In the model birth weight (p: 0.01, beta: -0.81) birth length (p: 0.05, beta: 0.41) and midarm-circumferences (p: 0.05, beta: 0.30) were the best predictors of lead levels, with the total variance explained being 36%. Significant relationship was found between birth weight and lead burden in newborns. Whether serum lead level predicts the development of failure to thrive in these children remains to be determined in follow-up studies. (c) 2006 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijheh.2006.06.007en_US
dc.identifier.endpage95en_US
dc.identifier.issn1438-4639en_US
dc.identifier.issue1en_US
dc.identifier.pmid16880005en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijheh.2006.06.007
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21572
dc.identifier.volume210en_US
dc.identifier.wosWOS:000244592600010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER GMBH, URBAN & FISCHER VERLAGen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcord blood lead levelsen_US
dc.subjectIGF-Ien_US
dc.subjectbirth sizeen_US
dc.subjectneonateen_US
dc.titleRelation of in utero lead exposure with insulin-like growth factor-I levels and neonatal anthropometric parametersen_US
dc.typeArticleen_US

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