Platelet glycoprotein Ib alpha gene polymorphism and massive or submassive pulmonary embolism

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dc.contributor.authorSoylu, Ahmet
dc.contributor.authorTokac, Mehmet
dc.contributor.authorCora, Tuelin
dc.contributor.authorDuzenli, Mehmet Akif
dc.contributor.authorAcar, Hasan
dc.date.accessioned2020-03-26T17:39:40Z
dc.date.available2020-03-26T17:39:40Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective The -5T/C polymorphism in the Kozak sequence of glycoprotein Ib alpha, a component of the platelet glycoprotein Ib-IX-V receptor complex, is associated with an increase in this receptor density on the surface of the platelet. This study was designed to investigate the effect of platelet glycoprotein Ib alpha Kozak polymorphism on the clinical presentation of the patients with acute pulmonary embolism. Methods Forty-two patients with pulmonary embolism were genotyped for Kozak polymorphism of the glycoprotein Ib alpha by polymerase chain reaction/restriction fragment length polymorphism. Results Carriers of the -5T/C polymorphism of glycoprotein Ib alpha were significantly over-represented in the patient group with clinically massive or submassive pulmonary embolism (odds ratio 5.5, 95% confidence interval 1.4 to 22.2, P = 0.023). Also the association between this polymorphism and massive or submassive pulmonary embolism still existed even after being adjusted for conventional risk factors. Conclusion The -5T/C polymorphism in the Kozak sequence of glycoprotein Ib alpha may present as a risk factor for clinical manifestation of pulmonary embolism in which clot burden plays an important role.en_US
dc.identifier.doi10.1007/s11239-008-0204-3en_US
dc.identifier.endpage266en_US
dc.identifier.issn0929-5305en_US
dc.identifier.issue3en_US
dc.identifier.pmid18283530en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage259en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11239-008-0204-3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23765
dc.identifier.volume27en_US
dc.identifier.wosWOS:000264886300002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF THROMBOSIS AND THROMBOLYSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPulmonary embolismen_US
dc.subjectKozak polymorphismen_US
dc.subjectGlycoprotein receptor complexen_US
dc.titlePlatelet glycoprotein Ib alpha gene polymorphism and massive or submassive pulmonary embolismen_US
dc.typeArticleen_US

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