Phototherapy causes a transient DNA damage in jaundiced newborns

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dc.contributor.authorKahveci, Hasan
dc.contributor.authorDogan, Hasan
dc.contributor.authorKaraman, Ali
dc.contributor.authorCaner, Ibrahim
dc.contributor.authorTastekin, Ayhan
dc.contributor.authorIkbal, Mevlit
dc.date.accessioned2020-03-26T18:42:53Z
dc.date.available2020-03-26T18:42:53Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, we aimed to clarify the following questions: 1) Does phototherapy (PT) cause genotoxicity in full-term newborn babies undergoing PT as a result of neonatal jaundice?, 2) if genotoxic effect occurs, is there any relationship between the duration of PT and genotoxicity?, and 3) is genotoxic effect temporary or not? The frequency of sister chromatid exchange (SCE) was determined in jaundiced newborns before, during, and after phototherapy, then determined again in childhood (approximately 3.5 years old). Mean frequency of SCE of 22 full-term jaundiced babies significantly increased during the PT procedure and in every single day, compared to the previous day, in comparison to the pre-PT basal value (6.20 +/- 0.57;); mean SCE frequencies at 24, 48, 72, and 96 hours were 7.75 +/- 0.40, 8.16 +/- 0.47, 8.50 +/- 0.40, and 9.36 +/- 0.55, respectively (all P-values < 0.01). In childhood, no significant difference was found between the mean SCE value (4.9 +/- 0.9) of 20 of 22 children, who received PT in the neonatal period, and the mean SCE value (4.7 +/- 0.6) of 20 coevaluated healthy children (P = 0.40). This study demonstrates that the negative effect of PT on SCE is a temporary effect.en_US
dc.identifier.doi10.3109/01480545.2011.653491en_US
dc.identifier.endpage92en_US
dc.identifier.issn0148-0545en_US
dc.identifier.issue1en_US
dc.identifier.pmid22360583en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://dx.doi.org/10.3109/01480545.2011.653491
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29728
dc.identifier.volume36en_US
dc.identifier.wosWOS:000311836600011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.relation.ispartofDRUG AND CHEMICAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNewbornen_US
dc.subjectphototherapyen_US
dc.subjectgenotoxicityen_US
dc.subjectsister chromatid exchangeen_US
dc.titlePhototherapy causes a transient DNA damage in jaundiced newbornsen_US
dc.typeArticleen_US

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