Haemostatic Role and Histopathological Effects of a New Haemostatic Agent in A Rat Bladder Haemorrhage Model: An Experimental Trial

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dc.contributor.authorKılıç, Özcan
dc.contributor.authorGönen, Murat
dc.contributor.authorAcar, Kadir
dc.contributor.authorYurdakul, Talat
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorEsen, Hacı Hasan
dc.contributor.authorÖz, Mehmet
dc.date.accessioned2020-03-26T17:48:58Z
dc.date.available2020-03-26T17:48:58Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVE To investigate the haemostatic efficacy and histopathological effects of a new haemostatic agent, Ankaferd BloodStopper (R) (ABS; Ankaferd Drug Cosmetic Co., Istanbul, Turkey) in a rat bladder haemorrhage model. ABS is a unique combination of five plant extracts that has been used in Turkish traditional medicine as a haemostatic agent for external traumatic bleeds. MATERIALS AND METHODS In all, 20 male Sprague-Dawley rats were divided into two equal groups. In both groups, the mucosa was damaged on the posterior wall (PW) of the bladder. The liquid form of ABS was applied to the bleeding area of one group (group 1) and 0.9% NaCl to the bleeding area of the other group (group 2, controls). The solutions were applied drop by drop with a 2 mL injector until the bleeding stopped and the bleeding times recorded. For histopathological examination, two tissue samples were taken from all rats in each group; one from the damaged mucosa in the PW and one from undamaged mucosa in the lateral wall (LW). Two sections were prepared from all samples. One section was stained with haematoxylin and eosin (H&E), and the rest was used for immunohistochemical staining for fibronectin. RESULTS The mean bleeding times were 65 s and 147 s for groups 1 and 2, respectively (P < 0.001). In the pathological specimens stained with H&E, fibrosis and other studied pathological features were similar in the LW samples in groups 1 and 2. Similarly, there were no differences between the PW samples of groups 1 and 2. In the pathological specimens stained for fibronectin, the number of attenuated cells was similar in the LWs of group 1 and 2 (P = 0.21) as well as in the PWs of each group (P = 0.066). CONCLUSIONS ABS decreased bleeding time and did not increase fibrotic reactions in rat bladder tissue.en_US
dc.identifier.citationKılıç, Ö., Gönen, M., Acar, K., Yurdakul, T., Avunduk, M. C., Esen, H. H., Öz, M., (2010). Haemostatic Role and Histopathological Effects of a New Haemostatic Agent in a Rat Bladder Haemorrhage Model: An Experimental Trial. BJU International, 105(12), 1722-1725. DOI:10.1111/j.1464-410X.2009.08985.x
dc.identifier.doi10.1111/j.1464-410X.2009.08985.xen_US
dc.identifier.endpage1725en_US
dc.identifier.issn1464-4096en_US
dc.identifier.issue12en_US
dc.identifier.pmid19849692en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1722en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1464-410X.2009.08985.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24970
dc.identifier.volume105en_US
dc.identifier.wosWOS:000278033700019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKılıç, Özcan
dc.institutionauthorAcar, Kadir
dc.institutionauthorYurdakul, Talat
dc.institutionauthorAvunduk, Mustafa Cihat
dc.institutionauthorEsen, Hacı Hasan
dc.institutionauthorÖz, Mehmet
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofBJU Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRatsen_US
dc.subjectBladderen_US
dc.subjectFibrosisen_US
dc.subjectBleedingen_US
dc.subjectHaemostatic Agenten_US
dc.titleHaemostatic Role and Histopathological Effects of a New Haemostatic Agent in A Rat Bladder Haemorrhage Model: An Experimental Trialen_US
dc.typeArticleen_US

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