Topiramate-Induced Changes in Anterior Chamber Angle and Choroidal Thickness

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dc.contributor.authorKaralezli, Aylin
dc.contributor.authorKoktekir, Bengu Ekinci
dc.contributor.authorCelik, Guner
dc.date.accessioned2020-03-26T19:31:46Z
dc.date.available2020-03-26T19:31:46Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To investigate the acute effects of topiramate on the anterior chamber angle (ACA) and choroidal thickness in patients with migraine. Methods: This prospective study included 15 eyes of 15 patients with migraine who have been scheduled to start topiramate therapy. All patients underwent complete ophthalmic examination including measurement of the ACA and choroidal thickness using a spectral domain optical coherence tomography device (Optovue Inc.) and refractive status evaluation with an autorefractokeratometer (KR-8100; Topcon) at the baseline and 1 week after starting therapy. The patients were asked to report any pain or discomfort in their eyes during therapy at the follow-up visit. Results: None of the patients experienced pain or discomfort in their eyes. The mean ACA significantly decreased at the first week of the therapy compared with the baseline levels (40.34 +/- 7.06 degrees and 36.89 +/- 6.87 degrees, respectively) (P=0.001). However, the mean choroidal thickness increased from 277.33 +/- 95.60 mu m at the baseline to 323.40 +/- 84.50 mu m at the first week (P=0.01). There was a nonsignificant increase in the mean refractive error (from -0.25 +/- 0.54 diopter [D] at the baseline to -0.38 +/- 0.49 D after 1 week) (P=0.06). Conclusions: Topiramate can acutely decrease the ACA and increase the choroidal thickness. Because these effects may be asymptomatic, patients with migraine who start this therapy should be warned to be closely followed up by an ophthalmologist.en_US
dc.identifier.doi10.1097/ICL.0000000000000157en_US
dc.identifier.endpage123en_US
dc.identifier.issn1542-2321en_US
dc.identifier.issn1542-233Xen_US
dc.identifier.issue2en_US
dc.identifier.pmid26020486en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://dx.doi.org/10.1097/ICL.0000000000000157
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34150
dc.identifier.volume42en_US
dc.identifier.wosWOS:000371747900006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofEYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMigraineen_US
dc.subjectTopiramateen_US
dc.subjectChoroidal thicknessen_US
dc.subjectAnterior chamber angleen_US
dc.titleTopiramate-Induced Changes in Anterior Chamber Angle and Choroidal Thicknessen_US
dc.typeArticleen_US

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