Determination of Allelic Deletion of Multiple Endocrine Neoplasm Type 1 (MEN1) Gene in Acute Myeloid Leukemia (AML) by Application of FISH-TSA Technique

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dc.contributor.authorAcar, Hasan
dc.contributor.authorKaynak, Murat
dc.contributor.authorYakut, Tahsin
dc.contributor.authorUçar, Fahri
dc.contributor.authorEgeli, Ünal
dc.date.accessioned2020-03-26T16:38:51Z
dc.date.available2020-03-26T16:38:51Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe have used the single and dual color fluorescence in situ hybridization (FISH) technique combined with a new detection system, tyramide signal amplification (TSA), by using the multiple endocrine neoplasm type I (MEN1) gene and chromosome I I specific alpha satellite DNA probes for the study of the allelic deletion of the MEN1 gene. The MEN1 gene is a new tumor supressor gene and has been recently cloned on chromosome 11q13. FISH combined with the TSA detection system was performed on bone marrow interphase nuclei of 22 patients with acute myeloid leukemia (AML). The FISH-TSA analysis revealed the mono allelic deletion of the MEN1 gene in 4 out of 22 patients (18.18%), 2 of 9 AML-M2 patients (22.2%), 1 of 6 AML-M4 patients (16.6%), and I of 4 AML-M5 patients (25.0%). Our study indicates that allelic deletion of the MEN1 gene is not a major cause or a primary event in tumorigenesis of AML, although the long arm (q13 region) of chromosome 11 involves a chromosomal rearrangement in AML.en_US
dc.identifier.citationAcar, H., Kaynak, M., Yakut, T., Uçar, F., Egeli, Ü., (2002). Determination of Allelic Deletion of Multiple Endocrine Neoplasm Type 1 (MEN1) Gene in Acute Myeloid Leukemia (AML) by Application of FISH-TSA Technique. Teratogenesis Carcinogenesis and Mutagenesis, (22), 369-375.
dc.identifier.doi10.1002/tcm.10033en_US
dc.identifier.endpage375en_US
dc.identifier.issn0270-3211en_US
dc.identifier.pmid12210500en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage369en_US
dc.identifier.urihttps://dx.doi.org/10.1002/tcm.10033
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17920
dc.identifier.volume22en_US
dc.identifier.wosWOS:000177779100007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAcar, Hasan
dc.institutionauthorKaynak, Murat
dc.language.isoenen_US
dc.publisherWiley-Lissen_US
dc.relation.ispartofTeratogenesis Carcinogenesis and Mutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAMLen_US
dc.subjectMEN1 geneen_US
dc.subjectallelic deletionen_US
dc.subjectFISHen_US
dc.subjectTSAen_US
dc.titleDetermination of Allelic Deletion of Multiple Endocrine Neoplasm Type 1 (MEN1) Gene in Acute Myeloid Leukemia (AML) by Application of FISH-TSA Techniqueen_US
dc.typeArticleen_US

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