High cholesterol diet leads to oxidant load and peroxidation in the rabbit kidney tissue

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dc.contributor.authorOzturk, B.
dc.contributor.authorOzer, O.
dc.contributor.authorDurak, Z. E.
dc.contributor.authorBillur, D.
dc.contributor.authorKizil, S.
dc.contributor.authorDurak, I
dc.contributor.authorOzturk, H. S.
dc.date.accessioned2020-03-26T19:24:29Z
dc.date.available2020-03-26T19:24:29Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVES: The aim of this study was to investigate possible effects of high cholesterol diet on oxidant/antioxidant status in rabbit kidney tissues. BACKGROUND:Although a number of experimental animal models have suggested that hyperlipidemia is associated with progressive kidney failure data remain sparse on the role of dietary cholesterol intake on kidney disease. METHODS: Twelve male New Zealand albino rabbits were randomly divided into two groups (control and cholesterol). Both groups were fed on a standard laboratory diet. Animals in the cholesterol group additionally received cholesterol (1 g/kg/day), orally. The study period was 12 weeks. Activities of catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), nitric oxide synthase (NOS), xanthine oxidase (XO), paraoxonase (PON), adenosine deaminase (ADA) enzymes and levels of malondialdehyde (MDA) and nitric oxide (NO) were measured in kidney tissue samples. Histological examination of the kidney tissue samples was also done. RESULTS: SOD, GSH-Px and XO enzyme activities were found to be decreased and NOS and PON activities increased significantly in cholesterol group compared to controls. As an indication of oxidation, MDA levels were found to be increased in cholesterol group. Histological examination revealed some derangements in the kidney tissue. CONCLUSION: High cholesterol diet creates oxidant load and causes peroxidation, which in turn, leads derangements in the rabbit kidney tissue (Tab. 2, Fig. 2, Ref. 69). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2016_045en_US
dc.identifier.endpage241en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue4en_US
dc.identifier.pmid27075389en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage235en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2016_045
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33663
dc.identifier.volume117en_US
dc.identifier.wosWOS:000374429300010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcholesterolen_US
dc.subjectoxidant / antioxidant systemen_US
dc.subjectkidneyen_US
dc.subjectrabbiten_US
dc.titleHigh cholesterol diet leads to oxidant load and peroxidation in the rabbit kidney tissueen_US
dc.typeArticleen_US

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