DETERMINATION OF DEFENSIN HNP-1 IN HUMAN SALIVA OF PATIENTS WITH ORAL MUCOSAL DISEASES

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dc.contributor.authorKucukkolbasi, Hasan
dc.contributor.authorKucukkolbasi, Semahat
dc.contributor.authorDursun, Recep
dc.contributor.authorAyyildiz, Filiz
dc.contributor.authorKara, Huseyin
dc.date.accessioned2020-03-26T18:14:06Z
dc.date.available2020-03-26T18:14:06Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractSaliva is a biological fluid that is easily obtainable and that can give useful information both in systemic and oral diseases. In this study, a chromatographic method was applied to determine the amount of defensin HNP-1 in human saliva of patients with oral mucosal diseases before and after treatments and compared with controls. Defensin human neutrophil peptide-1 (HNP-1) was identified and confirmed. The concentration of HNP-1 in saliva was determined by comparing the area of eluted HNP-1 with that of HNP-1 standard. Linear calibration range of defensin HNP-1 was 0.10 to 0.90 mu g/10 mu L with R(2) values of 0.996. The concentrations of HNP-1 in the saliva of patients with oral lichen planus, Behcet's disease, and recurrent apthous stomatitis were 33.6 +/- 10.6, 15.5 +/- 7.6, and 36.3 +/- 9.5 mu gmL(-1) (mean +/- S.D.), respectively. The salivary defensin-1 concentration was significantly higher in patients with oral mucosal diseases than in healthy volunteers; furthermore, in patients with oral mucosal diseases, the concentration was significantly higher before treatment than after treatment.en_US
dc.identifier.doi10.1080/15321819.2011.569045en_US
dc.identifier.endpage295en_US
dc.identifier.issn1532-1819en_US
dc.identifier.issue4en_US
dc.identifier.pmid21728821en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage284en_US
dc.identifier.urihttps://dx.doi.org/10.1080/15321819.2011.569045
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26306
dc.identifier.volume32en_US
dc.identifier.wosWOS:000293068700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofJOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdefensinen_US
dc.subjectHNP-1en_US
dc.subjectHPLCen_US
dc.subjectoral diseaseen_US
dc.subjectsalivaen_US
dc.titleDETERMINATION OF DEFENSIN HNP-1 IN HUMAN SALIVA OF PATIENTS WITH ORAL MUCOSAL DISEASESen_US
dc.typeArticleen_US

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