The Comparative Effects of Long-Term Carvedilol versus Bisoprolol Therapy on QT Dispersion in Patients with Chronic Heart Failure

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dc.contributor.authorAygul, Nazif
dc.contributor.authorOzdemir, Kurtulus
dc.contributor.authorDuzenli, Mehmet Akif
dc.contributor.authorAygul, Meryem Ulku
dc.date.accessioned2020-03-26T17:40:29Z
dc.date.available2020-03-26T17:40:29Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: Carvedilol and bisoprolol reduce QT dispersion (QTD) in chronic heart failure (CHF). However, it is unclear whether there is a difference between the effects of the two drugs. The aim of the present study was to compare the long-term effects of carvedilol and bisoprolol on QTD in patients with CHF. Methods: Eighty-one patients with CHF with no previous beta-blocker therapy were included in this prospective study. The patients were randomly allocated to carvedilol or bisoprolol therapy. Left ventricular ejection fraction (LVEF), heart rate (HR), QTD, and corrected QTD (QTcD) were calculated at baseline and at the 6th month of therapy. Results: In comparison to baseline values in both therapy groups, LVEF was significantly improved, and a statistically significant decrease was found in HR ( carvedilol from 76 +/- 12 to 65 +/- 10 beats/min, p < 0.001; bisoprolol from 78 +/- 13 to 65 +/- 8 beats/min, p < 0.001) and QTcD ( carvedilol from 85 +/- 28 to 65 +/- 22 ms, p < 0.001; bisoprolol from 83 8 22 to 61 8 20 ms, p ! 0.001). In our study, carvedilol and bisoprolol were found to have similar effects on LVEF, HR, and QTcD. Conclusions: Carvedilol and bisoprolol decrease HR and QTcD in patients with CHF, and there is no meaningful difference between the two beta-blockers as regards their effects on these parameters. Copyright (c) 2008 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000147950en_US
dc.identifier.endpage173en_US
dc.identifier.issn0008-6312en_US
dc.identifier.issue3en_US
dc.identifier.pmid18654081en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage168en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000147950
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23911
dc.identifier.volume112en_US
dc.identifier.wosWOS:000261978600002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofCARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBisoprololen_US
dc.subjectCarvedilolen_US
dc.subjectChronic heart failureen_US
dc.subjectQT dispersionen_US
dc.titleThe Comparative Effects of Long-Term Carvedilol versus Bisoprolol Therapy on QT Dispersion in Patients with Chronic Heart Failureen_US
dc.typeArticleen_US

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