Thyrotoxic hypokalaemic periodic paralysis in a Turkish population: three new case reports and analysis of the case series

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dc.contributor.authorCesur, Mustafa
dc.contributor.authorBayram, Fahri
dc.contributor.authorTemel, Mehtap Akcil
dc.contributor.authorOzkaya, Mesut
dc.contributor.authorKocer, Abdulkadir
dc.contributor.authorErtorer, Melek Eda
dc.contributor.authorKoc, Filiz
dc.date.accessioned2020-03-26T17:28:19Z
dc.date.available2020-03-26T17:28:19Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective Thyrotoxic hypokalaemic periodic paralysis (THPP) is an uncommon condition with intermittent episodes of muscle weakness and occasionally severe paralysis. THPP is a common complication of hyperthyroidism in Asian populations, and has also been reported in other ethnic groups including Caucasians. This study aimed to conduct an analysis of THPP in a Turkish population, and is to our knowledge the first analysis of a homogeneous Caucasian group. Subjects Forty cases with THPP were identified in the Turkish population. Three out of the 40 were new cases and were assigned as index cases. Two cases were not included in the analysis because of lack of data. Results THPP was diagnosed in 10 cases during the first attack and was observed to have a significant shorter complete recovery time statistically in this group (P < 0.01). The majority of cases were hypokalacmic, while there were two normokalaemic cases. Classification of the cases according to their potassium (K) levels revealed that the group with K levels < 2.5 mEq/l had a statistically longer amelioration time than the group with K levels >= 2.5 mEq/l. When the cases were classified according to intravenous or oral application of K, the mean amelioration time was 6.8 +/- 3.6 h for the intravenous group and 13.1 +/- 7.6 for the oral group. Mean complete recovery times of the groups were 29.4 +/- 16.2 h and 52.8 +/- 18.0 h, respectively. The intravenous group had a shorter amelioration time and complete recovery time, and both were statistically significant (P < 0.05 for each). Conclusions THPP may be seen among Caucasians. Diagnosing THPP during the first attack might decrease the recovery time. The level of hypokalaemia seems to affect the recovery time and initial low K levels may lead to more deterioration in a patient's health compared with mild or near-normal levels. Intravenous, rather than oral, application of K may be advantageous for shortening both the amelioration and complete recovery times.en_US
dc.identifier.doi10.1111/j.1365-2265.2007.03014.xen_US
dc.identifier.endpage152en_US
dc.identifier.issn0300-0664en_US
dc.identifier.issue1en_US
dc.identifier.pmid17897330en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1365-2265.2007.03014.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22756
dc.identifier.volume68en_US
dc.identifier.wosWOS:000252532800023en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBLACKWELL PUBLISHINGen_US
dc.relation.ispartofCLINICAL ENDOCRINOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThyrotoxic hypokalaemic periodic paralysis in a Turkish population: three new case reports and analysis of the case seriesen_US
dc.typeArticleen_US

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