Effect of vitamin A administration on free radicals and lactate levels in individuals exercised to exhaustion

Basit Öğe Kaydı
dc.contributor.authorPatlar, Süleyman
dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.contributor.authorMoğulkoç, Rasim
dc.date.accessioned2020-03-26T19:23:46Z
dc.date.available2020-03-26T19:23:46Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study was performed to explore the effect of vitamin A administration on Free Radicals production and antioxidant system activity and lactate levels in individuals exercised to exhaustion The study registered 10 healthy sedentary males their mean age was 22,85+/-0,26 years. The subjects were orally administrated with 300 mg vitamin A (retinol) for 4 weeks and engaged in strenuous exercise (using the Bruce protocol) once a week. Blood samples were collected from the subjects at four different times, before and after the supplementation and before and after exercise to analyze Malondialdehyde (MDA), Nitric oxide (NO), Glutathione (GSH), Glutathione peroxidase (GSH-Px), Catalase (CAT), Superoxide dismutase (SOD) levels using colorimetric ELISA test kits and plasma lactate levels using an autoanalyzer. Exhaustion exercise leaded to an increase in both MDA, NO, and lactate, and GSH, GSH-Px, CAT and SOD levels compared to resting levels both before and after supplementation (p<0.05). Increased NO levels found in pre-supplementation exhaustion showed a significant decrease after the supplementation of vitamin A (p<0.05), but the other parameters were not changed after vitamin A administration. The results of our study demonstrate that the increase caused by 4-week strenuous exercise in the levels of the free radical NO was offset by vitamin A supplementation. It can be suggested that supplementation of vitamin A at physiological doses has a limited effect on lipid peroxidation caused by strenuous exercise.en_US
dc.description.sponsorshipSelcuk University (BAP)Selcuk University [09401079]en_US
dc.description.sponsorshipAuthors would like to Scientific Research Project of Selcuk University for grant (BAP, project number is 09401079).en_US
dc.identifier.endpage1534en_US
dc.identifier.issn1011-601Xen_US
dc.identifier.issue5en_US
dc.identifier.pmid27731808en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1531en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33491
dc.identifier.volume29en_US
dc.identifier.wosWOS:000384389600010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUNIV KARACHIen_US
dc.relation.ispartofPAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectVitamin Aen_US
dc.subjectexerciseen_US
dc.subjectfree radicalsen_US
dc.subjectantioxidant activityen_US
dc.subjectlactateen_US
dc.titleEffect of vitamin A administration on free radicals and lactate levels in individuals exercised to exhaustionen_US
dc.typeArticleen_US

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