Comparison of the ganglion cell complex and retinal nerve fibre layer measurements using Fourier domain optical coherence tomography to detect ganglion cell loss in non-arteritic anterior ischaemic optic neuropathy

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dc.contributor.authorGonul, Saban
dc.contributor.authorKoktekir, Bengu Ekinci
dc.contributor.authorBakbak, Berker
dc.contributor.authorGedik, Sansal
dc.date.accessioned2020-03-26T18:41:21Z
dc.date.available2020-03-26T18:41:21Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective To evaluate the diagnostic ability of macular ganglion cell complex (GCC) and peripapillary nerve fibre layer (NFL) measurements to detect ganglion cell loss (GCL) in patients with non-arteritic anterior ischaemic optic neuropathy (NAION), at the chronic stage. Methods This study included 10 eyes from 10 patients with NAION and 15 eyes from 15 age-matched healthy subjects. The measurements included the GCC thicknesses as average, superior and inferior, the GCC parameters as focal loss volume (FLV) and global loss volume (GLV), the NFL thicknesses as average, superior hemisphere and inferior hemisphere, and the disc parameters as rim area and rim volume. The curves for the area under the receiver operator characteristic (AUROC) were generated to assess the ability of each parameter to detect GCL. Results The patient group had significantly lower GCC thicknesses than the control group (p<0.001, <0.001 and 0.004, for the GCC average, superior and inferior, respectively), and also significantly higher FLV and GLV measurements (p<0.001). The NFL thicknesses were found to be significantly lower in the patient group than the control subjects (p<0.001). Among all the parameters, the FLV and the GLV had the highest levels of AUROC values (1.000, 0.990, respectively). Conclusions The FLV and the GLV showed the strongest abilities to detect GCL in patients with NAION. In addition, peripapillary NFL thickness was comparable to macular GCC thickness in detecting GCL. Therefore, macular GCC scans may provide a good alternative or a complementary practice to NFL scans in the detection of GCL in patients with NAION.en_US
dc.identifier.doi10.1136/bjophthalmol-2013-303438en_US
dc.identifier.endpage1050en_US
dc.identifier.issn0007-1161en_US
dc.identifier.issn1468-2079en_US
dc.identifier.issue8en_US
dc.identifier.pmid23759443en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1045en_US
dc.identifier.urihttps://dx.doi.org/10.1136/bjophthalmol-2013-303438
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29323
dc.identifier.volume97en_US
dc.identifier.wosWOS:000322039400022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBMJ PUBLISHING GROUPen_US
dc.relation.ispartofBRITISH JOURNAL OF OPHTHALMOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectOptic Nerveen_US
dc.subjectDiagnostic testsen_US
dc.subjectInvestigationen_US
dc.titleComparison of the ganglion cell complex and retinal nerve fibre layer measurements using Fourier domain optical coherence tomography to detect ganglion cell loss in non-arteritic anterior ischaemic optic neuropathyen_US
dc.typeArticleen_US

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